Total saponins from Panax Japonicus regulate the ferritin heavy chain to reduce inflammation in aging adipose tissue by mediating iron metabolism

IF 6.8 2区医学 Q1 CHEMISTRY, MEDICINAL

Journal of Ginseng Research Pub Date : 2024-11-19 DOI:10.1016/j.jgr.2024.11.001

Leiqi Zhu , Jihong Zhang , Yaqi Hu , Yifan Zhang , Shuwen Wang , Rui Wang , Qi Yuan , Yiyang Luo , Ding Yuan , Yumin He , Chengfu Yuan

{"title":"Total saponins from Panax Japonicus regulate the ferritin heavy chain to reduce inflammation in aging adipose tissue by mediating iron metabolism","authors":"Leiqi Zhu , Jihong Zhang , Yaqi Hu , Yifan Zhang , Shuwen Wang , Rui Wang , Qi Yuan , Yiyang Luo , Ding Yuan , Yumin He , Chengfu Yuan","doi":"10.1016/j.jgr.2024.11.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Inflammation is a key factor contributing to aging-related morbidities. Inflammation is intimately linked to the iron metabolism in macrophages, and ferritin heavy chain (Fth) is the basis of iron metabolism in macrophages. Regulating Fth to control iron metabolism may help to reduce inflammation in macrophages, which can ultimately help to alleviate certain aging-related diseases.</div></div><div><h3>Methods</h3><div>The effects of total saponins from <em>Panax Japonicus</em> (TSPJs) in the intervention of aging-related obesity were explored. The <em>in vitro</em> and <em>in vivo</em> models were established using RAW264.7 macrophage cells and naturally aging rats and mice. The inflammation, iron content, and gene expressions of the models were analyzed. Senescence was induced in RAW264.7 cells with adriamycin (ADR), and Fth knockdown was introduced to the models to investigate related mechanisms.</div></div><div><h3>Results</h3><div>TSPJs reduced the iron content in the macrophages and prompted M2 polarization, which affected the JNK signaling pathway (<em>p</em> < 0.05) and reduced the expression of inflammatory cytokines in adipose tissue.</div></div><div><h3>Conclusion</h3><div>TSPJs mediate the iron metabolism of macrophages via Fth to reduce aging-related inflammation of the adipose tissue.</div></div>","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":"49 2","pages":"Pages 134-144"},"PeriodicalIF":6.8000,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Ginseng Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1226845324001544","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Inflammation is a key factor contributing to aging-related morbidities. Inflammation is intimately linked to the iron metabolism in macrophages, and ferritin heavy chain (Fth) is the basis of iron metabolism in macrophages. Regulating Fth to control iron metabolism may help to reduce inflammation in macrophages, which can ultimately help to alleviate certain aging-related diseases.

Methods

The effects of total saponins from Panax Japonicus (TSPJs) in the intervention of aging-related obesity were explored. The in vitro and in vivo models were established using RAW264.7 macrophage cells and naturally aging rats and mice. The inflammation, iron content, and gene expressions of the models were analyzed. Senescence was induced in RAW264.7 cells with adriamycin (ADR), and Fth knockdown was introduced to the models to investigate related mechanisms.

Results

TSPJs reduced the iron content in the macrophages and prompted M2 polarization, which affected the JNK signaling pathway (p < 0.05) and reduced the expression of inflammatory cytokines in adipose tissue.

Conclusion

TSPJs mediate the iron metabolism of macrophages via Fth to reduce aging-related inflammation of the adipose tissue.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE

CiteScore

11.40

自引率

9.50%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.