New treatments for acromegaly: Is a revolution underway?

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Annales d'endocrinologie Pub Date : 2025-02-15 DOI:10.1016/j.ando.2025.101710

Justine Cristante , Frédéric Castinetti

引用次数: 0

Abstract

The first-line treatment for acromegaly is transsphenoidal surgery. Somatostatin receptor ligands are usually prescribed if surgery fails, or, in some patients, as pre-surgical medical treatment. The efficacy and tolerance of first-generation somatostatin receptor ligands is well established, but they incur unmet medical needs due to their mode of administration and side effects. We report results for new compounds that may be used in the near future as alternatives to first-generation somatostatin receptor ligands, with data on efficacy and tolerance: oral octreotide, paltusotine and long-acting subcutaneous octreotide are reviewed in detail, together with potential new compounds under investigation. We also discuss their potential role in the therapeutic armamentarium for acromegaly.

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肢端肥大症的新疗法：一场革命正在进行吗？

肢端肥大症的一线治疗是经蝶窦手术。生长抑素受体配体通常在手术失败时开处方，或者在一些患者中，作为手术前的药物治疗。第一代生长抑素受体配体的疗效和耐受性已经得到了很好的证实，但由于它们的给药方式和副作用，它们引起了未满足的医疗需求。我们报告了可能在不久的将来用作第一代生长抑素受体配体替代品的新化合物的结果，包括疗效和耐受性的数据：口服奥曲肽，paltusotide和长效皮下奥曲肽进行了详细回顾，以及正在研究的潜在新化合物。我们还讨论了它们在肢端肥大症治疗中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annales d'endocrinologie 医学-内分泌学与代谢

CiteScore

4.40

自引率

6.50%

发文量

311

审稿时长

50 days

期刊介绍： The Annales d''Endocrinologie, mouthpiece of the French Society of Endocrinology (SFE), publishes reviews, articles and case reports coming from clinical, therapeutic and fundamental research in endocrinology and metabolic diseases. Every year, it carries a position paper by a work-group of French-language endocrinologists, on an endocrine pathology chosen by the Society''s Scientific Committee. The journal is also the organ of the Society''s annual Congress, publishing a summary of the symposia, presentations and posters. "Les Must de l''Endocrinologie" is a special booklet brought out for the Congress, with summary articles that are always very well received. And finally, we publish the high-level instructional courses delivered during the Henri-Pierre Klotz International Endocrinology Days. The Annales is a window on the world, keeping alert clinicians up to date on what is going on in diagnosis and treatment in all the areas of our specialty.