Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review.

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Hendrik Schmieder, Christian Leischner, Alban Piotrowsky, Luigi Marongiu, Sascha Venturelli, Markus Burkard
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引用次数: 0

Abstract

The importance of vitamin D for a well-functioning immune system is becoming increasingly evident. Nevertheless, the other fat-soluble vitamins A, E and K also seem to play a central role regarding the adequate function of immune cells and to counteract excessive immune reactions and inflammatory processes. However, recognizing hidden hunger, particularly micronutrient deficiencies in vulnerable groups like the elderly, is crucial because older adults often lack sufficient micronutrients for various reasons. This review summarizes the latest findings on the immune modulating functions of fat-soluble vitamins in a physiological and pathophysiological context, provides a graphical comparison of the Recommended Daily Allowances between Deutschland, Austria, Confoederatio Helvetica (D-A-CH; eng. GSA, Germany, Switzerland, Austria), Deutsche Gesellschaft für Ernährung (DGE; eng. German Nutrition Society) and National Institutes of Health (NIH) across all age groups and, in particular, addresses the question regarding the benefits of supplementation of the respective micronutrients for the aging population of industrialized nations to strengthen the immune system. The following review highlights the importance of fat-soluble vitamins A, D, E and K which play critical roles in maintaining immune system function and, in some cases, in preventing excessive immune activation. Therefore, a better understanding of the relevance of adequate blood levels and consequently potential supplementation strategies may contribute to the prevention and management of infectious diseases as well as better overall health of the elderly.

探索脂溶性维生素与衰老相关免疫系统状态之间的联系:文献综述。
维生素D对免疫系统功能良好的重要性越来越明显。然而,其他脂溶性维生素A、E和K似乎也在免疫细胞的适当功能和抵消过度的免疫反应和炎症过程中发挥核心作用。然而,认识到隐性饥饿,特别是老年人等弱势群体的微量营养素缺乏,是至关重要的,因为老年人往往由于各种原因缺乏足够的微量营养素。本文综述了脂溶性维生素在生理和病理生理方面的免疫调节功能的最新发现,并提供了德国、奥地利、德国、德国、德国和德国推荐日摄入量的图形比较。eng。GSA,德国,瑞士,奥地利),德国经济合作协会 Ernährung (DGE;eng。德国营养学会(German Nutrition Society)和美国国立卫生研究院(National Institutes of Health, NIH)对所有年龄组的研究,尤其针对工业化国家的老龄人口补充相应微量营养素以增强免疫系统的益处的问题。下面的综述强调了脂溶性维生素A、D、E和K的重要性,它们在维持免疫系统功能方面起着关键作用,在某些情况下,还可以防止过度的免疫激活。因此,更好地了解充足血液水平的相关性以及由此产生的潜在补充策略可能有助于预防和管理传染病以及改善老年人的整体健康状况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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