Genotypic analysis of human papillomavirus in cervical exfoliated cells from women in Zigong.

IF 4 3区 医学 Q2 VIROLOGY
Xiaoyang Ma, Chuan Wu, Tao Wu, Xiaolin Yu, Lixing Song
{"title":"Genotypic analysis of human papillomavirus in cervical exfoliated cells from women in Zigong.","authors":"Xiaoyang Ma, Chuan Wu, Tao Wu, Xiaolin Yu, Lixing Song","doi":"10.1186/s12985-025-02652-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study investigated the human papillomavirus (HPV) infection status among women in Zigong from January 2016 to August 2024 and provides a comprehensive statistical analysis of HPV infection characteristics. The findings aim to enhance cervical cancer screening, inform vaccination strategies, and improve HPV infection prevention measures.</p><p><strong>Methods: </strong>We conducted a retrospective analysis on 48,474 female patients who visited the gynecology department of Zigong Fourth People's Hospital from January 2016 to August 2024. Cervical exfoliated cell samples were collected from the patients, and the genotypes of 10 low-risk HPV (LR-HPV) and 17 high-risk HPV (HR-HPV) were detected by flow fluorescent hybridization technique. The study explored HPV infection rates, genotype distribution, number of infections, type of infections, and age distribution. The chi-squared (χ<sup>2</sup>) test was employed to compare infection statuses between groups.</p><p><strong>Results: </strong>Among the 48,474 patients, 9749 tested positive for HPV, with an overall infection rate of 20.11%. The HPV infection rate increased gradually from 2016 to 2024 (P < 0.001). The infection rates of single, double, triple, and ≥ quadruple infections were 15.11%, 3.54%, 1.00%, and 0.46%, respectively. The infection rates were 4.41% for LR-HPV-only, 13.13% for HR-HPV-only, and 2.57% for mixed LR and HR-HPV. HR-HPV primarily consisted of HPV types 52, 16, 53, and 58, with infection rates of 3.94%, 2.71%, 2.43%, and 2.42%, respectively. LR-HPV primarily consisted of types 61 and 81, with infection rates of 1.64% and 1.49%, respectively. A significant age correlation in HPV infection was observed (P < 0.001), with two distinct peaks in infection rates.</p><p><strong>Conclusions: </strong>The HPV infection rate among women visiting the gynecology department in Zigong is high, predominantly involving HPV types 52, 16, 53, and 58. Therefore, strengthening HPV screening efforts and focusing on standardized genotype screening is crucial. Additionally, selecting HPV vaccines targeting prevalent genotypes and actively conducting HPV prevention and control work can reduce the incidence of HPV-related cervical cancer and other HPV-related diseases.</p>","PeriodicalId":23616,"journal":{"name":"Virology Journal","volume":"22 1","pages":"40"},"PeriodicalIF":4.0000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831773/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virology Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12985-025-02652-7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VIROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: This study investigated the human papillomavirus (HPV) infection status among women in Zigong from January 2016 to August 2024 and provides a comprehensive statistical analysis of HPV infection characteristics. The findings aim to enhance cervical cancer screening, inform vaccination strategies, and improve HPV infection prevention measures.

Methods: We conducted a retrospective analysis on 48,474 female patients who visited the gynecology department of Zigong Fourth People's Hospital from January 2016 to August 2024. Cervical exfoliated cell samples were collected from the patients, and the genotypes of 10 low-risk HPV (LR-HPV) and 17 high-risk HPV (HR-HPV) were detected by flow fluorescent hybridization technique. The study explored HPV infection rates, genotype distribution, number of infections, type of infections, and age distribution. The chi-squared (χ2) test was employed to compare infection statuses between groups.

Results: Among the 48,474 patients, 9749 tested positive for HPV, with an overall infection rate of 20.11%. The HPV infection rate increased gradually from 2016 to 2024 (P < 0.001). The infection rates of single, double, triple, and ≥ quadruple infections were 15.11%, 3.54%, 1.00%, and 0.46%, respectively. The infection rates were 4.41% for LR-HPV-only, 13.13% for HR-HPV-only, and 2.57% for mixed LR and HR-HPV. HR-HPV primarily consisted of HPV types 52, 16, 53, and 58, with infection rates of 3.94%, 2.71%, 2.43%, and 2.42%, respectively. LR-HPV primarily consisted of types 61 and 81, with infection rates of 1.64% and 1.49%, respectively. A significant age correlation in HPV infection was observed (P < 0.001), with two distinct peaks in infection rates.

Conclusions: The HPV infection rate among women visiting the gynecology department in Zigong is high, predominantly involving HPV types 52, 16, 53, and 58. Therefore, strengthening HPV screening efforts and focusing on standardized genotype screening is crucial. Additionally, selecting HPV vaccines targeting prevalent genotypes and actively conducting HPV prevention and control work can reduce the incidence of HPV-related cervical cancer and other HPV-related diseases.

求助全文
约1分钟内获得全文 求助全文
来源期刊
Virology Journal
Virology Journal 医学-病毒学
CiteScore
7.40
自引率
2.10%
发文量
186
审稿时长
1 months
期刊介绍: Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信