Genotypic analysis of human papillomavirus in cervical exfoliated cells from women in Zigong.

IF 4 3区 医学 Q2 VIROLOGY
Xiaoyang Ma, Chuan Wu, Tao Wu, Xiaolin Yu, Lixing Song
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Abstract

Background: This study investigated the human papillomavirus (HPV) infection status among women in Zigong from January 2016 to August 2024 and provides a comprehensive statistical analysis of HPV infection characteristics. The findings aim to enhance cervical cancer screening, inform vaccination strategies, and improve HPV infection prevention measures.

Methods: We conducted a retrospective analysis on 48,474 female patients who visited the gynecology department of Zigong Fourth People's Hospital from January 2016 to August 2024. Cervical exfoliated cell samples were collected from the patients, and the genotypes of 10 low-risk HPV (LR-HPV) and 17 high-risk HPV (HR-HPV) were detected by flow fluorescent hybridization technique. The study explored HPV infection rates, genotype distribution, number of infections, type of infections, and age distribution. The chi-squared (χ2) test was employed to compare infection statuses between groups.

Results: Among the 48,474 patients, 9749 tested positive for HPV, with an overall infection rate of 20.11%. The HPV infection rate increased gradually from 2016 to 2024 (P < 0.001). The infection rates of single, double, triple, and ≥ quadruple infections were 15.11%, 3.54%, 1.00%, and 0.46%, respectively. The infection rates were 4.41% for LR-HPV-only, 13.13% for HR-HPV-only, and 2.57% for mixed LR and HR-HPV. HR-HPV primarily consisted of HPV types 52, 16, 53, and 58, with infection rates of 3.94%, 2.71%, 2.43%, and 2.42%, respectively. LR-HPV primarily consisted of types 61 and 81, with infection rates of 1.64% and 1.49%, respectively. A significant age correlation in HPV infection was observed (P < 0.001), with two distinct peaks in infection rates.

Conclusions: The HPV infection rate among women visiting the gynecology department in Zigong is high, predominantly involving HPV types 52, 16, 53, and 58. Therefore, strengthening HPV screening efforts and focusing on standardized genotype screening is crucial. Additionally, selecting HPV vaccines targeting prevalent genotypes and actively conducting HPV prevention and control work can reduce the incidence of HPV-related cervical cancer and other HPV-related diseases.

自贡市妇女宫颈脱落细胞中人乳头瘤病毒基因型分析。
背景:本研究对2016年1月至2024年8月自贡市女性人乳头瘤病毒(HPV)感染情况进行调查,对HPV感染特征进行综合统计分析。研究结果旨在加强宫颈癌筛查,为疫苗接种策略提供信息,并改善HPV感染预防措施。方法:对2016年1月至2024年8月在自贡市第四人民医院妇科就诊的48474例女性患者进行回顾性分析。采集患者宫颈脱落细胞样本,采用流式荧光杂交技术检测10例低危型HPV (LR-HPV)和17例高危型HPV (HR-HPV)的基因型。该研究探讨了HPV感染率、基因型分布、感染数量、感染类型和年龄分布。采用χ2检验比较各组感染情况。结果:48474例患者中,9749例HPV检测阳性,总感染率为20.11%。结论:自贡市妇科就诊妇女HPV感染率较高,以HPV 52型、16型、53型和58型为主。因此,加强HPV筛查工作和注重标准化基因型筛查是至关重要的。此外,选择针对流行基因型的HPV疫苗,积极开展HPV防控工作,可以降低HPV相关宫颈癌和其他HPV相关疾病的发病率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Virology Journal
Virology Journal 医学-病毒学
CiteScore
7.40
自引率
2.10%
发文量
186
审稿时长
1 months
期刊介绍: Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.
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