{"title":"Ocular manifestations of Juvenile Systemic Lupus Erythematosus: a systematic review.","authors":"Anna Nikolaidou, Theodora Gianni, Athanasia Sandali, Panagiotis Toumasis, Konstantinos Benekos, Efthymia Tsina","doi":"10.1038/s41433-025-03664-x","DOIUrl":null,"url":null,"abstract":"<p><p>Juvenile-onset Systemic Lupus Erythematosus (JSLE) is a chronic multifactorial autoimmune disease with multiple system involvement, affecting children and adolescents. Ocular manifestations are rare and can range from mild to severe. JSLE impacts quality of life and prognosis. However, the impact JSLE has on children's ocular health remains an underexplored area. This systematic review aims to consolidate existing evidence on ocular manifestations in JSLE. A systematic search of MEDLINE and ScienceDirect was conducted until October 2024. Eligible studies focused on children and adolescents with JSLE presenting ocular symptoms. Joanna Briggs Institute critical appraisal tools for each study were employed for quality assessment. Forty-two studies evaluating ocular manifestations in JSLE patients were included. Among those were 29 case reports and case series with 34 patients in total, 4 cross-sectional studies, with a total of 210 patients, 155 of whom had ocular manifestations, and 9 cohort studies, with a total of 2696 patients enrolled and 212 of them reporting ocular manifestations (7.8%). Results were categorized by affected ocular structures: external, anterior, or posterior segment. Neuro-ophthalmological and drug-induced manifestations were described separately. Retinal involvement was the most often reported. Notable manifestations included dry eye disease, uveitis, vaso-occlusive retinopathy, and corticosteroid-induced cataracts. Ocular symptoms often served as the initial indication of disease onset. Heightened awareness and standardized assessments are necessary for management of ocular manifestations. Further research is needed to comprehensively elucidate the underlying mechanisms and pathogenesis of the disease.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eye","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41433-025-03664-x","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Juvenile-onset Systemic Lupus Erythematosus (JSLE) is a chronic multifactorial autoimmune disease with multiple system involvement, affecting children and adolescents. Ocular manifestations are rare and can range from mild to severe. JSLE impacts quality of life and prognosis. However, the impact JSLE has on children's ocular health remains an underexplored area. This systematic review aims to consolidate existing evidence on ocular manifestations in JSLE. A systematic search of MEDLINE and ScienceDirect was conducted until October 2024. Eligible studies focused on children and adolescents with JSLE presenting ocular symptoms. Joanna Briggs Institute critical appraisal tools for each study were employed for quality assessment. Forty-two studies evaluating ocular manifestations in JSLE patients were included. Among those were 29 case reports and case series with 34 patients in total, 4 cross-sectional studies, with a total of 210 patients, 155 of whom had ocular manifestations, and 9 cohort studies, with a total of 2696 patients enrolled and 212 of them reporting ocular manifestations (7.8%). Results were categorized by affected ocular structures: external, anterior, or posterior segment. Neuro-ophthalmological and drug-induced manifestations were described separately. Retinal involvement was the most often reported. Notable manifestations included dry eye disease, uveitis, vaso-occlusive retinopathy, and corticosteroid-induced cataracts. Ocular symptoms often served as the initial indication of disease onset. Heightened awareness and standardized assessments are necessary for management of ocular manifestations. Further research is needed to comprehensively elucidate the underlying mechanisms and pathogenesis of the disease.
期刊介绍:
Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists.
Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.