Association between ultra-processed food consumption and inflammation: insights from the STANISLAS cohort.

IF 4.3 2区医学 Q2 NUTRITION & DIETETICS

European Journal of Nutrition Pub Date : 2025-02-17 DOI:10.1007/s00394-025-03607-y

Lea Lin Chun Hu Xia, Nicolas Girerd, Zohra Lamiral, Kevin Duarte, Ludovic Merckle, Celine Leroy, Julie-Anne Nazare, Laurie Van Den Berghe, Louise Seconda, Axelle Hoge, Michèle Guillaume, Martine Laville, Patrick Rossignol, Jean-Marc Boivin, Sandra Wagner

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引用次数: 0

Abstract

Purpose: High consumption of ultra-processed food (UPF) is associated with an increased risk of developing chronic diseases. Inflammation may be one of the underlying mechanisms behind this association. However, only a limited number of studies have investigated the association between UPF consumption and a few selected inflammation biomarkers, yielding inconsistent results. This study aimed to assess the cross-sectional association between UPF consumption (as a whole and 10 sub-categories), and 78 circulating proteins related to inflammation.

Methods: The present study included 1594 adult participants from the STANISLAS cohort. UPF consumption was estimated using the NOVA classification, and linear regression models were used to assess their association with circulating proteins.

Results: UPFs accounted for 28% of the total energy intake and 5.7 servings on average per day. In the unadjusted model, 15 circulating proteins had a significant association with UPF consumption. After adjustment, only (FGF-19) was significantly associated with UPF consumption (β = - 0.02[- 0.03; - 0.003]).

Conclusion: UPF consumption was negatively associated with Fibroblast Growth Factor 19 (FGF-19) serum levels. When considering UPF sub-categories, no circulating proteins were associated with dairy products and dairy desserts. Of note, circulating proteins were differentially associated depending on the sub-category of UPF. Further studies are needed to better understand the link between UPF and inflammation.

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超加工食品消费与炎症之间的关系：来自STANISLAS队列的见解

目的：过量食用超加工食品（UPF）与患慢性疾病的风险增加有关。炎症可能是这种关联背后的潜在机制之一。然而，只有有限数量的研究调查了UPF消耗与一些选定的炎症生物标志物之间的关系，结果不一致。本研究旨在评估UPF消耗（整体和10个子类别）与78种与炎症相关的循环蛋白之间的横断面关联。方法：本研究包括来自STANISLAS队列的1594名成人参与者。使用NOVA分类估计UPF消耗，并使用线性回归模型评估其与循环蛋白的关联。结果：upf占总能量摄入的28%，平均每天5.7份。在未调整的模型中，15种循环蛋白与UPF消耗显著相关。调整后，只有（FGF-19）与UPF消耗显著相关（β = - 0.02[- 0.03; - 0.003]）。结论：UPF消耗与成纤维细胞生长因子19 （FGF-19）血清水平呈负相关。当考虑UPF子类别时，没有与乳制品和乳制品甜点相关的循环蛋白质。值得注意的是，根据UPF的子类别，循环蛋白的相关性存在差异。需要进一步的研究来更好地了解UPF和炎症之间的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Nutrition 医学-营养学

CiteScore

10.20

自引率

2.00%

发文量

295

审稿时长

6 months

期刊介绍： The European Journal of Nutrition publishes original papers, reviews, and short communications in the nutritional sciences. The manuscripts submitted to the European Journal of Nutrition should have their major focus on the impact of nutrients and non-nutrients on immunology and inflammation, gene expression, metabolism, chronic diseases, or carcinogenesis, or a major focus on epidemiology, including intervention studies with healthy subjects and with patients, biofunctionality of food and food components, or the impact of diet on the environment.