Association Between Diet Quality Enhancement and Lower Metabolic Endotoxemia in Women with Different Body Mass Index: A Case-Control Study.

IF 1.9 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Alternative therapies in health and medicine Pub Date : 2025-02-14

Çiler Özenir, Üçler Kisa, Serdar Güler, Aylin Ayaz

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引用次数: 0

Abstract

Background: Chronic low-grade inflammation can cause obesity, with diet playing an important role in promoting or reducing inflammation.

Primary study objective: Examining the relationship between diet quality and the soluble cluster of differentiation 14 (sCD14), lipopolysaccharide (LPS), lipopolysaccharide binding protein (LBP), and toll-like receptor-4 (TLR4) levels in obese individuals compared to healthy people.

Methods/design: Body weight, height, waist, hip, and neck circumference were measured, and body mass index (BMI), waist/hip, and waist/height ratio were calculated. Tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), high sensitive C-reactive protein (hs-CRP), LPS, LBP, sCD14, and TLR4 were analysed. Diet Quality Index-International was calculated using the 3-day food consumption record.

Setting: Conducted in Ankara Numune Training and Research Hospital Endocrine Outpatient Clinic in Turkey.

Participants: 40 women of ages 20-45 with no systemic disease and a BMI between 30.0-39.9 kg/m2 were enrolled in the case group; while 40 healthy women with BMI and age distribution similar to the case group were enrolled in the control group.

Intervention: Anthropometric measurements, blood samples, and food consumption records were collected.

Results: While there was no statistically significant difference between the case and control groups in serum sCD14, LPS, LBP, and TLR4 levels (P > .05), the difference in IL-6, TNF-α, and hsCRP levels was found to be statistically significant (P < .05). The mean Diet Quality Index-International total score was 49.88 ± 6.29 in the case group and 54.77 ± 7.41 in the control group (P < .05). A low-level, negative, but significant relationship was detected between the serum sCD14, LBP, and TLR4 means of the case and control groups and Diet Quality Index-International total score. It was determined that a high Diet Quality Index-International total score was correlated with decreased IL-6, TNF-α, hsCRP, sCD14, and TLR4.

Conclusion: Increased nutritional quality in women with different BMI was associated with lower metabolic endotoxemia.

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来源期刊

Alternative therapies in health and medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

0.90

自引率

0.00%

发文量

219

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