Association Between Recurrent Aphthous Ulcers and Oral Biodiversity: A Systematic Review and Meta-Analysis

IF 3.6 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Journal of Evidence‐Based Medicine Pub Date : 2025-02-19 DOI:10.1111/jebm.70001

Lin Zhao, Hongyu Xie, Lunwei Kang, Ga Liao

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引用次数: 0

Abstract

Objective

This study aimed to investigate the relationship between recurrent aphthous ulcers (RAU) and dysbiosis of the oral microbiota.

Methods

A systematic search was conducted across several databases, including the Cochrane Library, PubMed, Web of Science Core Collection, Embase, Scopus, CBM, CNKI, WanFang, and VIP, to identify relevant studies from the inception of the library until September 20, 2024. All included studies were evaluated for quality using the Newcastle–Ottawa scale. These studies assessed the diversity and abundance of oral microorganisms in patients with RAU in comparison to healthy individuals. Results were synthesized via random-effects meta-analysis (I² statistic for heterogeneity). Mean differences (MD) and 95% confidence intervals (CI) were applied to evaluate the pooled effects of outcomes. The systematic review was registered in PROSPERO (CRD42024615516).

Results

A total of 10 studies involving 343 patients and 348 controls were included in this study, 7 of these were utilized for meta-analysis to conduct a quantitative assessment. The meta-analysis showed that in terms of alpha diversity, saliva samples collected from patients with RAU exhibited a significantly lower Chao 1 index of alpha diversity (MD = –41.22, 95% CI –64.34 to –18.09, p < 0.01), and that patients with ulcerated sites in the oral mucosa demonstrated a higher Chao 1 index when compared to healthy sites within the oral mucosa (MD = 27.48, 95% CI 2.98 to 51.97, p = 0.03).

Conclusions

Significant differences in the Chao 1 index between patients and healthy controls, along with variations in beta diversity and the relative abundance of taxa, indicate that microbial dysbiosis may play a crucial role in the development of RAU.

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复发性阿弗顿溃疡与口腔生物多样性的关系：一项系统综述和荟萃分析

目的探讨复发性阿弗顿溃疡（RAU）与口腔菌群失调的关系。方法系统检索Cochrane Library、PubMed、Web of Science Core Collection、Embase、Scopus、CBM、CNKI、万方、VIP等数据库，检索自Cochrane Library建库至2024年9月20日的相关研究。所有纳入的研究均采用纽卡斯尔-渥太华量表进行质量评估。这些研究评估了与健康个体相比，RAU患者口腔微生物的多样性和丰度。结果通过随机效应荟萃分析（I2统计量为异质性）综合。采用平均差异（MD）和95%置信区间（CI）来评估结果的综合效应。该系统评价已在PROSPERO注册（CRD42024615516）。结果本研究共纳入10项研究，共纳入343例患者和348例对照，其中7项纳入meta分析进行定量评价。meta分析显示，在α多样性方面，RAU患者唾液样本的α多样性Chao - 1指数显著降低(MD = -41.22, 95% CI -64.34 ~ -18.09, p <；口腔黏膜溃疡部位患者的Chao 1指数高于口腔黏膜健康部位患者（MD = 27.48, 95% CI 2.98 ~ 51.97, p = 0.03）。结论患者与健康对照组Chao 1指数存在显著差异，β多样性和类群相对丰度也存在差异，表明微生物生态失调可能在RAU的发生发展中起关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Evidence‐Based Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

11.20

自引率

1.40%

发文量

期刊介绍： The Journal of Evidence-Based Medicine (EMB) is an esteemed international healthcare and medical decision-making journal, dedicated to publishing groundbreaking research outcomes in evidence-based decision-making, research, practice, and education. Serving as the official English-language journal of the Cochrane China Centre and West China Hospital of Sichuan University, we eagerly welcome editorials, commentaries, and systematic reviews encompassing various topics such as clinical trials, policy, drug and patient safety, education, and knowledge translation.