Integrated Seroprevalence and Genome-Based Study of SARS-CoV-2 Viral Strains in N′Djamena: Insights Into Chad's COVID-19 Epicenter

IF 6.8 3区医学 Q1 VIROLOGY

Journal of Medical Virology Pub Date : 2025-02-18 DOI:10.1002/jmv.70234

Mathiew Hota, Andrillene L. D. Wondeu, Mahamat F. Abakar, Koutaya Dezoumbe, Fatima Abdelrazakh, Sabrina Atturo, Nathan Naïbeï, Giulia Cappelli, Franck Mennechet, Fissou H. Yandai, Djamal H. Abdallah, Zongo R. F. Edgard, Abdoulaye Boukar, Choroma A. Moussa, Issa M. Yaya, Mahamat I. Hamad, Nontegyol Armand, Netalar Honorine, Kayanlengar Frederic, Adam A. Moustapha, Yanda M. Daniel, Adam M. Alim, Mahamat Grene, Oumaima Djarma, Noubaramadji Y. Suitombaye, Amine Akouya, Ouchemi Choua, Guy R. T. Dzomo, Djallaye Djimtoïbaye, Vittorio Colizzi, Mahamat A. Moussa, Marta Giovanetti

{"title":"Integrated Seroprevalence and Genome-Based Study of SARS-CoV-2 Viral Strains in N′Djamena: Insights Into Chad's COVID-19 Epicenter","authors":"Mathiew Hota, Andrillene L. D. Wondeu, Mahamat F. Abakar, Koutaya Dezoumbe, Fatima Abdelrazakh, Sabrina Atturo, Nathan Naïbeï, Giulia Cappelli, Franck Mennechet, Fissou H. Yandai, Djamal H. Abdallah, Zongo R. F. Edgard, Abdoulaye Boukar, Choroma A. Moussa, Issa M. Yaya, Mahamat I. Hamad, Nontegyol Armand, Netalar Honorine, Kayanlengar Frederic, Adam A. Moustapha, Yanda M. Daniel, Adam M. Alim, Mahamat Grene, Oumaima Djarma, Noubaramadji Y. Suitombaye, Amine Akouya, Ouchemi Choua, Guy R. T. Dzomo, Djallaye Djimtoïbaye, Vittorio Colizzi, Mahamat A. Moussa, Marta Giovanetti","doi":"10.1002/jmv.70234","DOIUrl":null,"url":null,"abstract":"<p>The COVID-19 epidemic has shown regional variations in transmission and outcomes. As a primary hotspot in Chad, N'Djamena is crucial for comprehensive epidemiological investigation. Our study employed two methodologies: seroprevalence data collection and whole-genome sequencing of SARS-CoV-2 strains. This dual approach assessed population exposure and virus genetic diversity. Seroprevalence data indicated broader exposure than confirmed cases suggested, and genome sequencing identified multiple strains, including globally recognized variants of concern. Integrating these data provided insights into transmission dynamics, potential herd immunity thresholds, and the impact of specific variants on disease progression. Our findings underscore the importance of integrated, multidisciplinary research in infectious disease epidemiology and inform targeted public health strategies, including social measures and vaccination, to combat infectious diseases in N'Djamena.</p>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 2","pages":""},"PeriodicalIF":6.8000,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.70234","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Virology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jmv.70234","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VIROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The COVID-19 epidemic has shown regional variations in transmission and outcomes. As a primary hotspot in Chad, N'Djamena is crucial for comprehensive epidemiological investigation. Our study employed two methodologies: seroprevalence data collection and whole-genome sequencing of SARS-CoV-2 strains. This dual approach assessed population exposure and virus genetic diversity. Seroprevalence data indicated broader exposure than confirmed cases suggested, and genome sequencing identified multiple strains, including globally recognized variants of concern. Integrating these data provided insights into transmission dynamics, potential herd immunity thresholds, and the impact of specific variants on disease progression. Our findings underscore the importance of integrated, multidisciplinary research in infectious disease epidemiology and inform targeted public health strategies, including social measures and vaccination, to combat infectious diseases in N'Djamena.

Abstract Image

查看原文本刊更多论文

对 N′Djamena 的 SARS-CoV-2 病毒株进行血清流行率和基于基因组的综合研究：洞察乍得的 COVID-19 中心

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Medical Virology 医学-病毒学

CiteScore

23.20

自引率

2.40%

发文量

777

审稿时长

1 months

期刊介绍： The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.