A Latent Profile Analysis of Psychosis Symptoms to Examine Distress and Depression as Pathways to Suicide Ideation Among Individuals in an Early Phase of Psychosis Illness

IF 2.1 4区医学 Q3 PSYCHIATRY

Early Intervention in Psychiatry Pub Date : 2025-02-18 DOI:10.1111/eip.70013

Lindsay A. Bornheimer, Nicholas M. Brdar, Adrienne Lapidos, Alexandra N. Kelter, Chloe Miner, Andrew Grogan-Kaylor

{"title":"A Latent Profile Analysis of Psychosis Symptoms to Examine Distress and Depression as Pathways to Suicide Ideation Among Individuals in an Early Phase of Psychosis Illness","authors":"Lindsay A. Bornheimer, Nicholas M. Brdar, Adrienne Lapidos, Alexandra N. Kelter, Chloe Miner, Andrew Grogan-Kaylor","doi":"10.1111/eip.70013","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Suicide rates are high among individuals in first episode psychosis and there is a critical need to better understand drivers of suicide risk to inform treatment efforts. This study identified profiles of psychosis symptoms and examined a mediation model of depression and distress as mechanisms in the relationships between psychosis symptoms and suicide ideation by latent profiles.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Data were obtained from the Human Connectome Project for Early Psychosis (<i>n</i> = 166) of individuals between 16 and 35 years of age who had onset of affective or non-affective psychosis within 5 years of consent. Data were analysed using Latent Profile Analysis (LPA) and Structural Equation Modelling in MPlus.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>LPA revealed the following groups: (1) relatively lower and more balanced levels of symptoms, (2) highest positive and general symptoms and (3) highest negative symptoms. Findings indicated the relationships in the model differed between by LPA groups. Distress and depression functioned as mediators between psychosis symptoms and suicide ideation for Groups 1 and 2.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>A better understanding of the roles that distress and depression play in the relationships between psychosis symptoms and suicide ideation can help inform modifiable targets of early intervention and subsequently decrease risk for suicide.</p>\n </section>\n </div>","PeriodicalId":11385,"journal":{"name":"Early Intervention in Psychiatry","volume":"19 2","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eip.70013","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Early Intervention in Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/eip.70013","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Suicide rates are high among individuals in first episode psychosis and there is a critical need to better understand drivers of suicide risk to inform treatment efforts. This study identified profiles of psychosis symptoms and examined a mediation model of depression and distress as mechanisms in the relationships between psychosis symptoms and suicide ideation by latent profiles.

Methods

Data were obtained from the Human Connectome Project for Early Psychosis (n = 166) of individuals between 16 and 35 years of age who had onset of affective or non-affective psychosis within 5 years of consent. Data were analysed using Latent Profile Analysis (LPA) and Structural Equation Modelling in MPlus.

Results

LPA revealed the following groups: (1) relatively lower and more balanced levels of symptoms, (2) highest positive and general symptoms and (3) highest negative symptoms. Findings indicated the relationships in the model differed between by LPA groups. Distress and depression functioned as mediators between psychosis symptoms and suicide ideation for Groups 1 and 2.

Conclusions

A better understanding of the roles that distress and depression play in the relationships between psychosis symptoms and suicide ideation can help inform modifiable targets of early intervention and subsequently decrease risk for suicide.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Early Intervention in Psychiatry 医学-精神病学

CiteScore

4.80

自引率

5.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： Early Intervention in Psychiatry publishes original research articles and reviews dealing with the early recognition, diagnosis and treatment across the full range of mental and substance use disorders, as well as the underlying epidemiological, biological, psychological and social mechanisms that influence the onset and early course of these disorders. The journal provides comprehensive coverage of early intervention for the full range of psychiatric disorders and mental health problems, including schizophrenia and other psychoses, mood and anxiety disorders, substance use disorders, eating disorders and personality disorders. Papers in any of the following fields are considered: diagnostic issues, psychopathology, clinical epidemiology, biological mechanisms, treatments and other forms of intervention, clinical trials, health services and economic research and mental health policy. Special features are also published, including hypotheses, controversies and snapshots of innovative service models.