Chemical constituents from the fruits of Forsythia suspensa and their chemotaxonomic significance

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Systematics and Ecology Pub Date : 2025-02-18 DOI:10.1016/j.bse.2025.104984

Sui Liu , Xiang-Xin Niu , Jun-Lei He , Chang-Hua Yue , Zi-Xiao Jiang , Zhang-Xin Yu , Yang-Yang Liu

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引用次数: 0

Abstract

A new labdane diterpenoid (4R,5R,7R,9R,10R)-methyl-7-hydroxylabda-8(17),13(E)-diene-18-carboxy-15-oate (1), along with three known analogues (2–4), a cyclohexenone derivative (5), three phenolic acids (6–8) and four lignan compounds (9–12), were isolated from the fruits of Forsythia suspensa. The structures were elucidated using comprehensive spectroscopic methods, including HRESIMS, 1D and 2D NMR, the absolute configuration of 1 was established based on quantum-chemical electronic circular dichroism (ECD) calculations. The compounds 1–5, 9, and 11 were evaluated for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced mouse monocyte macrophage (RAW 264.7) cells, as well as for their anti-cervical cancer activity. However, none of these compounds exhibited significant activity at a concentration of 50 μM. Notably, compounds 1, 5, 9, and 11 were reported here for the first time from the genus Forsythia, and this is also the first discovery of a cyclohexenone derivative within this genus. These findings contribute to the growing understanding of the chemical diversity and chemotaxonomic significance of F. suspensa.

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来源期刊

Biochemical Systematics and Ecology 生物-进化生物学

CiteScore

3.00

自引率

12.50%

发文量

147

审稿时长

43 days

期刊介绍： Biochemical Systematics and Ecology is devoted to the publication of original papers and reviews, both submitted and invited, in two subject areas: I) the application of biochemistry to problems relating to systematic biology of organisms (biochemical systematics); II) the role of biochemistry in interactions between organisms or between an organism and its environment (biochemical ecology). In the Biochemical Systematics subject area, comparative studies of the distribution of (secondary) metabolites within a wider taxon (e.g. genus or family) are welcome. Comparative studies, encompassing multiple accessions of each of the taxa within their distribution are particularly encouraged. Welcome are also studies combining classical chemosystematic studies (such as comparative HPLC-MS or GC-MS investigations) with (macro-) molecular phylogenetic studies. Studies that involve the comparative use of compounds to help differentiate among species such as adulterants or substitutes that illustrate the applied use of chemosystematics are welcome. In contrast, studies solely employing macromolecular phylogenetic techniques (gene sequences, RAPD studies etc.) will be considered out of scope. Discouraged are manuscripts that report known or new compounds from a single source taxon without addressing a systematic hypothesis. Also considered out of scope are studies using outdated and hard to reproduce macromolecular techniques such as RAPDs in combination with standard chemosystematic techniques such as GC-FID and GC-MS.