A stress-driven model for bone density evolution in rats during orthodontic tooth movement

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-02-10 DOI:10.1016/j.jmbbm.2025.106932

Bin Wu , Mingna Li , Fan Yang , Yi Lu , Yang Yi , Mao Liu , Ke Cheng , Di Jiang , Bin Yan

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引用次数: 0

Abstract

Orthodontic bone remodeling simulations offer a scientific foundation for optimizing treatment plans and predicting outcomes in orthodontics. Since alveolar bone exhibits unique regional responses and high sensitivity to tensile and compressive stresses, traditional models often fail to account for these characteristics, limiting their accuracy in predicting the microstructural changes of alveolar bone under external forces. To address this issue, this study proposes a bone remodeling model based on equivalent stress derived from the Mohr strength theory as the mechanical stimulus. The model differentiates tension and compression zones within the alveolar bone and simulates density changes driven by the orthodontic remodeling process: bone formation in tension zone and resorption in compression zone. Orthodontic experiments on rats were conducted to monitor changes in alveolar bone density at 7 and 14 days. Results revealed a density increase of around 3.16% and 9.84% in tension zone and a decrease of approximately 4.86% and 3.61% in compression zone on days 7 and 14, respectively. A comparison between the experimental data and the simulation results of the bone remodeling algorithm demonstrated a consistent trend, validating that the proposed model effectively reflects the dynamic process of bone remodeling. This study provides a new perspective for orthodontic bone remodeling simulations and lays a foundation for further exploration of the mechanisms underlying alveolar bone density changes.

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正畸牙齿移动过程中大鼠骨密度演化的应力驱动模型

正畸骨重塑模拟为优化正畸治疗方案和预测结果提供了科学依据。由于牙槽骨表现出独特的区域反应和对拉伸和压缩应力的高度敏感性，传统模型往往不能考虑这些特征，从而限制了其预测牙槽骨在外力作用下微结构变化的准确性。为了解决这一问题，本研究提出了一种基于Mohr强度理论的等效应力作为机械刺激的骨重塑模型。该模型区分了牙槽骨内的张力区和压缩区，并模拟了正畸重塑过程驱动的密度变化：张力区骨形成和压缩区骨吸收。采用正畸实验监测大鼠牙槽骨密度在第7天和第14天的变化。结果表明，第7天和第14天，张力区密度分别增加约3.16%和9.84%，压缩区密度分别减少约4.86%和3.61%。骨重塑算法的实验数据与仿真结果的对比显示出一致的趋势，验证了所提出的模型有效地反映了骨重塑的动态过程。本研究为正畸骨重塑模拟提供了新的视角，为进一步探索牙槽骨密度变化的机制奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.