Interpenetrating polymer networks of poly (2-hydroxyethyl methacrylate co-itaconic acid) and chitosan as a controlled release matrix

IF 4.5 3区工程技术 Q1 CHEMISTRY, APPLIED

Reactive & Functional Polymers Pub Date : 2025-02-14 DOI:10.1016/j.reactfunctpolym.2025.106192

N.E. Valderruten, J. García

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Abstract

Interpenetrating networks of chitosan and poly (2-hydroxyethyl methacrylate co-itaconic acid) p(HEMA-co-IA) were synthesized. FTIR spectra confirmed the crosslinking of chitosan and the polymerization and crosslinking of 2-hydroxyethyl methacrylate (HEMA) with itaconic acid (IA). Swelling properties were studied at different pH levels, and it was shown that such properties depend primarily on chitosan and itaconic acid content and the sensitivity to pH of the network components. The degradation of the materials obtained was performed with lysozyme under simulated physiological conditions. Increased degradation was observed with increasing copolymer content (p(HEMA-co-IA)) in the hydrogel. Creep-recovery analysis studies demonstrated that the materials exhibit viscoelastic behavior, resulting in lower instantaneous deformation of the interpenetrating hydrogels and higher shear modulus. Diclofenac sodium was used as a model drug for controlled release studies. The results indicate that the incorporation of the copolymer increased the concentration of drug released by the hydrogel.

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来源期刊

Reactive & Functional Polymers 工程技术-高分子科学

CiteScore

8.90

自引率

5.90%

发文量

259

审稿时长

27 days

期刊介绍： Reactive & Functional Polymers provides a forum to disseminate original ideas, concepts and developments in the science and technology of polymers with functional groups, which impart specific chemical reactivity or physical, chemical, structural, biological, and pharmacological functionality. The scope covers organic polymers, acting for instance as reagents, catalysts, templates, ion-exchangers, selective sorbents, chelating or antimicrobial agents, drug carriers, sensors, membranes, and hydrogels. This also includes reactive cross-linkable prepolymers and high-performance thermosetting polymers, natural or degradable polymers, conducting polymers, and porous polymers. Original research articles must contain thorough molecular and material characterization data on synthesis of the above polymers in combination with their applications. Applications include but are not limited to catalysis, water or effluent treatment, separations and recovery, electronics and information storage, energy conversion, encapsulation, or adhesion.