{"title":"Antidepressant-induced Hyponatremia in Postmenopausal Females: A Case Series.","authors":"Prabhat Kumar Agrawal, Sandipta Kumar Panda, Shiv Sagar Yadav, Ruchika Garg, Ashish Gautam","doi":"10.4103/jmh.jmh_206_24","DOIUrl":null,"url":null,"abstract":"<p><p>Hyponatremia is the most common electrolyte imbalance observed in hospitalized as well as outdoor patients. Antidepressants such as selective serotonin receptor inhibitors and tricyclic antidepressants are reported among the most common drugs causing hyponatremia, especially in the elderly and in patients with known risk factors for hyponatremia. However, there have been only a few case reports of hyponatremia associated with antidepressants such as mirtazapine and flupentixol/melitracen. The exact mechanism of hyponatremia with the use of antidepressants is not known; however, syndrome of inappropriate antidiuretic hormone secretion (SIADH) is presumed to be the reason. Here, we report two cases of antidepressant drug-induced hyponatremia in two postmenopausal females with no other risk factor for hyponatremia: one associated with mirtazapine and the other with flupentixol/melitracen.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"15 4","pages":"313-314"},"PeriodicalIF":1.2000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824925/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Mid-life Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jmh.jmh_206_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/2 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Hyponatremia is the most common electrolyte imbalance observed in hospitalized as well as outdoor patients. Antidepressants such as selective serotonin receptor inhibitors and tricyclic antidepressants are reported among the most common drugs causing hyponatremia, especially in the elderly and in patients with known risk factors for hyponatremia. However, there have been only a few case reports of hyponatremia associated with antidepressants such as mirtazapine and flupentixol/melitracen. The exact mechanism of hyponatremia with the use of antidepressants is not known; however, syndrome of inappropriate antidiuretic hormone secretion (SIADH) is presumed to be the reason. Here, we report two cases of antidepressant drug-induced hyponatremia in two postmenopausal females with no other risk factor for hyponatremia: one associated with mirtazapine and the other with flupentixol/melitracen.
期刊介绍：
Journal of mid-life health is the official journal of the Indian Menopause society published Quarterly in January, April, July and October. It is peer reviewed, scientific journal of mid-life health and its problems. It includes all aspects of mid-life health, preventive as well as curative. The journal publishes on subjects such as gynecology, neurology, geriatrics, psychiatry, endocrinology, urology, andrology, psychology, healthy ageing, cardiovascular health, bone health, quality of life etc. as relevant of men and women in their midlife. The Journal provides a visible platform to the researchers as well as clinicians to publish their experiences in this area thereby helping in the promotion of mid-life health leading to healthy ageing, growing need due to increasing life expectancy. The Editorial team has maintained high standards and published original research papers, case reports and review articles from the best of the best contributors both national & international, consistently so that now, it has become a great tool in the hands of menopause practitioners.
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