[A Case of Advanced Gastric Cancer with Massive Lymph Node Metastases Greatly Decreased in Size after Chemotherapy with Nivolumab and SOX].

Q4 Medicine
Ruiichiro Morita, Yukihiro Kato, Hanae Matsuda, Takuya Kikukawa, Atsushi Isihara, Yasunori Matsuda, Seikann Miyashita, Masahiro Nishikawa, Takahiro Uenishi, Yuuko Kuwae, Masahiko Osawa
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引用次数: 0

Abstract

A 81-year-old woman was referred to our department for further examination and treatment after upper gastrointestinal endoscopy revealed a type 3 tumor in the antrum. CT scan revealed a primary tumor with extramural invasion in the antrum and large lymph nodes bordering the pancreas, as well as in the right side of cardia. A diagnosis of advanced gastric cancer cT4aN2M0, cStage Ⅲ was made. She was administered chemotherapy with nivolumab and SOX. After 2 courses of treatment, CT scan showed marked reduction of the primary tumor and lymph nodes. Therefore, laparoscopic gastrectomy(D2 dissection+Roux-en-Y reconstruction)was performed. Histopathological findings showed that the primary tumor was confined to the sub serosal tissue and no lymph node metastases were observed. The patient is currently alive without recurrence and treated with S-1 monotherapy. Chemotherapy with nivolumab and SOX is considered to be an effective treatment strategy for advanced gastric cancer with advanced lymph node metastases.

[尼武单抗联合SOX化疗后晚期胃癌淋巴结转移肿大缩小1例]。
一名81岁妇女在上消化道内镜检查发现胃窦3型肿瘤后转介至我科接受进一步检查和治疗。CT扫描显示原发肿瘤外侵于胃窦,胰腺周围有大淋巴结,以及贲门右侧。诊断为晚期胃癌cT4aN2M0, cStageⅢ。她接受了纳武单抗和SOX的化疗。治疗2个疗程后,CT扫描显示原发肿瘤及淋巴结明显缩小。因此行腹腔镜胃切除术(D2夹层+Roux-en-Y重建)。组织病理学结果显示原发肿瘤局限于浆膜下组织,未见淋巴结转移。该患者目前存活,无复发,并接受S-1单药治疗。nivolumab和SOX联合化疗被认为是晚期胃癌伴晚期淋巴结转移的有效治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
0.20
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