Impulsivity facets and substance use involvement: insights from genomic structural equation modeling.

IF 5.9 2区 医学 Q1 PSYCHIATRY
Laura Vilar-Ribó, Alexander S Hatoum, Andrew D Grotzinger, Travis T Mallard, Sarah Elson, Pierre Fontanillas, Abraham A Palmer, Daniel E Gustavson, Sandra Sanchez-Roige
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引用次数: 0

Abstract

Background: Impulsivity is a multidimensional trait associated with substance use disorders (SUDs), but the relationship between distinct impulsivity facets and stages of substance use involvement remains unclear.

Methods: We used genomic structural equation modeling and genome-wide association studies (N = 79,729-903,147) to examine the latent genetic architecture of nine impulsivity traits and seven substance use (SU) and SUD traits.

Results: We found that the SU and SUD factors were strongly genetically inter-correlated (rG=0.77) but their associations with impulsivity facets differed. Lack of premeditation, negative and positive urgency were equally positively genetically correlated with both the SU (rG=.0.30-0.50) and SUD (rG=0.38-0.46) factors; sensation seeking was more strongly genetically correlated with the SU factor (rG=0.27 versus rG=0.10); delay discounting was more strongly genetically correlated with the SUD factor (rG=0.31 versus rG=0.21); and lack of perseverance was only weakly genetically correlated with the SU factor (rG=0.10). After controlling for the genetic correlation between SU/SUD, we found that lack of premeditation was independently genetically associated with both the SU (β=0.42) and SUD factors (β=0.21); sensation seeking and positive urgency were independently genetically associated with the SU factor (β=0.48, β=0.33, respectively); and negative urgency and delay discounting were independently genetically associated with the SUD factor (β=0.33, β=0.36, respectively).

Conclusions: Our findings show that specific impulsivity facets confer risk for distinct stages of substance use involvement, with potential implications for SUDs prevention and treatment.

冲动方面和物质使用参与:从基因组结构方程模型的见解。
背景:冲动性是一种与物质使用障碍(sud)相关的多维特征,但冲动性不同方面与物质使用涉及阶段之间的关系尚不清楚。方法:采用基因组结构方程模型和全基因组关联研究(N = 79,729-903,147),分析了9个冲动性状和7个物质使用(SU)和SUD性状的潜在遗传结构。结果:我们发现,SU和SUD因素具有很强的遗传相关性(rG=0.77),但它们与冲动方面的相关性不同。缺乏预谋、阴性和阳性急迫性与SU (rG= 0.0.30 -0.50)和SUD (rG=0.38-0.46)因素具有同等的遗传正相关;感觉寻求与SU因素的基因相关性更强(rG=0.27 vs rG=0.10);延迟折扣与SUD因素的遗传相关性更强(rG=0.31比rG=0.21);缺乏毅力与SU因子的遗传相关性较弱(rG=0.10)。在控制了SU/SUD的遗传相关性后,我们发现缺乏预谋与SU (β=0.42)和SUD (β=0.21)都有独立的遗传相关性;感觉寻求和积极急迫性与SU因子有独立的遗传相关性(β=0.48, β=0.33);负紧迫感和延迟折扣与SUD因子具有独立的遗传相关性(β=0.33, β=0.36)。结论:我们的研究结果表明,特定的冲动因素会给物质使用的不同阶段带来风险,这对预防和治疗sud具有潜在的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Psychological Medicine
Psychological Medicine 医学-精神病学
CiteScore
11.30
自引率
4.30%
发文量
711
审稿时长
3-6 weeks
期刊介绍: Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.
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