Lina De Paola, Gabriele Napoletano, Giuseppe Gullo, Francesco Circosta, Gianluca Montanari Vergallo, Susanna Marinelli
{"title":"The era of increasing cancer survivorship: Trends in fertility preservation, medico-legal implications, and ethical challenges.","authors":"Lina De Paola, Gabriele Napoletano, Giuseppe Gullo, Francesco Circosta, Gianluca Montanari Vergallo, Susanna Marinelli","doi":"10.1515/med-2025-1144","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Global cancer cases are increasing, but fortunately, cancer is becoming more treatable. By 2050, the number of cancer cases is projected to reach 35 million. These numbers are certainly correlated with the aging population, early diagnoses due to screenings, and the broad current treatment options. However, life-saving therapies are often gonadotoxic, significantly impacting the lives of cancer patients. Fertility preservation following life-saving oncological treatments is one of the challenges faced by patients with cancer.</p><p><strong>Material and method: </strong>We analyzed 73 articles to investigate the current state of fertility preservation in oncology, also evaluating the medico-legal implications.</p><p><strong>Results: </strong>The data indicate a growing trend of cancer recoveries and survivorship with opportunities to access fertility preservation through various methods, which are not entirely known or consistently offered to patients in the appropriate manner.</p><p><strong>Conclusions: </strong>The ethical and medico-legal aspects are numerous and seem to be still evolving.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251144"},"PeriodicalIF":1.7000,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826245/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/med-2025-1144","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Global cancer cases are increasing, but fortunately, cancer is becoming more treatable. By 2050, the number of cancer cases is projected to reach 35 million. These numbers are certainly correlated with the aging population, early diagnoses due to screenings, and the broad current treatment options. However, life-saving therapies are often gonadotoxic, significantly impacting the lives of cancer patients. Fertility preservation following life-saving oncological treatments is one of the challenges faced by patients with cancer.
Material and method: We analyzed 73 articles to investigate the current state of fertility preservation in oncology, also evaluating the medico-legal implications.
Results: The data indicate a growing trend of cancer recoveries and survivorship with opportunities to access fertility preservation through various methods, which are not entirely known or consistently offered to patients in the appropriate manner.
Conclusions: The ethical and medico-legal aspects are numerous and seem to be still evolving.
期刊介绍:
Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.