Autoimmunity in long COVID

IF 11.4 1区 医学 Q1 ALLERGY
Shubha Talwar MRes, James A. Harker PhD, Peter J.M. Openshaw MD, PhD, Ryan S. Thwaites PhD
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引用次数: 0

Abstract

Long COVID (also termed postacute sequelae of SARS-CoV-2, or PASC) affects up to 10% of people recovering from infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Diagnosis is hampered by diffuse symptomatology, lack of biomarkers, incomplete understanding of pathogenesis, and lack of validated treatments. In terms of pathogenesis, hypothesized causes include virus persistence, the legacy of endotheliitis and thrombosis, low-grade tissue-based inflammation and/or scarring, perturbation of the host virome/microbiome, or triggering of autoimmunity. Several studies show preexisting and/or de novo production of autoantibodies after infection with SARS-CoV-2, but the persistence of these antibodies and their role in causing long COVID is debated. Here, we review the mechanisms through which autoimmune responses can arise during and after viral infection, focusing on the evidence for B-cell dysregulation and autoantibody production in acute and long COVID.
长冠病毒的自身免疫。
长冠状病毒(也称为SARS-CoV-2急性后后遗症或PASC)影响多达10%的SARS-CoV-2感染恢复期患者。诊断受到弥漫性症状、缺乏生物标志物、对发病机制的不完全了解以及缺乏有效治疗的阻碍。在发病机制方面,假设的原因包括病毒持续存在,内皮炎和血栓形成的遗留,低级别组织炎症和/或瘢痕形成,宿主病毒组/微生物组的扰动,或触发自身免疫。几项研究表明,感染SARS-CoV-2后存在预先存在和/或重新产生的自身抗体,但这些抗体的持久性及其在引起长期covid中的作用仍存在争议。在这里,我们回顾了自身免疫反应在病毒感染期间和之后产生的机制,重点关注急性和长期covid中b细胞失调和自身抗体产生的证据。
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来源期刊
CiteScore
25.90
自引率
7.70%
发文量
1302
审稿时长
38 days
期刊介绍: The Journal of Allergy and Clinical Immunology is a prestigious publication that features groundbreaking research in the fields of Allergy, Asthma, and Immunology. This influential journal publishes high-impact research papers that explore various topics, including asthma, food allergy, allergic rhinitis, atopic dermatitis, primary immune deficiencies, occupational and environmental allergy, and other allergic and immunologic diseases. The articles not only report on clinical trials and mechanistic studies but also provide insights into novel therapies, underlying mechanisms, and important discoveries that contribute to our understanding of these diseases. By sharing this valuable information, the journal aims to enhance the diagnosis and management of patients in the future.
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