Compact and aberration effects-shielded objective intraocular scatter measurement system.

Abstract

The measurement of the double-pass (DP) point spread function (PSF) provides an objective, non-invasive method for estimating intraocular scatter in the human eye. In this paper, we propose a compact double-pass objective intraocular scatter measurement system that eliminates the influence of aberrations. The system includes a far-field DP PSF detection channel and a Shack-Hartmann wavefront aberration detection channel, which are used to obtain the far-field DP PSF image and 7 orders Zernike aberration coefficients, respectively. The far-field DP PSF image is used to calculate the initial objective scatter index of the human eye. The aberration coefficients are used to reconstruct the DP PSF image caused by aberrations and calculate the influence coefficient of aberrations on intraocular scatter. By subtracting this influence coefficient from the initial objective scatter index (OSI0), the effect of aberrations on scatter measurement can be eliminated, resulting in an accurate objective scatter coefficient. Experimental verification showed that when the exit pupil aperture of this system was set to 4 mm and 6 mm, the measurement accuracy increased by at least 11.9% and 28.9%, respectively, compared to before eliminating the influence of aberrations. While improving the measurement accuracy, the system also keeps the device size and manufacturing costs at a low level, making it more suitable for clinical applications.