Compact and aberration effects-shielded objective intraocular scatter measurement system.

IF 2.9 2区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Biomedical optics express Pub Date : 2025-01-27 eCollection Date: 2025-02-01 DOI:10.1364/BOE.545245

Junlei Zhao, Zitao Zhang, Yanrong Yang, Haobo Zhang, Hao Chen, Shengqian Wang, Yun Dai

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引用次数: 0

Abstract

The measurement of the double-pass (DP) point spread function (PSF) provides an objective, non-invasive method for estimating intraocular scatter in the human eye. In this paper, we propose a compact double-pass objective intraocular scatter measurement system that eliminates the influence of aberrations. The system includes a far-field DP PSF detection channel and a Shack-Hartmann wavefront aberration detection channel, which are used to obtain the far-field DP PSF image and 7 orders Zernike aberration coefficients, respectively. The far-field DP PSF image is used to calculate the initial objective scatter index of the human eye. The aberration coefficients are used to reconstruct the DP PSF image caused by aberrations and calculate the influence coefficient of aberrations on intraocular scatter. By subtracting this influence coefficient from the initial objective scatter index (OSI0), the effect of aberrations on scatter measurement can be eliminated, resulting in an accurate objective scatter coefficient. Experimental verification showed that when the exit pupil aperture of this system was set to 4 mm and 6 mm, the measurement accuracy increased by at least 11.9% and 28.9%, respectively, compared to before eliminating the influence of aberrations. While improving the measurement accuracy, the system also keeps the device size and manufacturing costs at a low level, making it more suitable for clinical applications.

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紧凑和像差效应屏蔽物镜眼内散射测量系统。

双通道（DP）点扩散函数（PSF）的测量为估计人眼的眼内散射提供了一种客观、无创的方法。在本文中，我们提出了一种紧凑的双通道物镜眼内散射测量系统，消除了像差的影响。该系统包括远场DP PSF检测通道和Shack-Hartmann波前像差检测通道，分别用于获取远场DP PSF图像和7阶Zernike像差系数。利用远场DP PSF图像计算人眼初始物镜散射指数。利用像差系数重构由像差引起的DP PSF图像，并计算像差对眼内散射的影响系数。通过从初始物镜散射指数（OSI0）中减去该影响系数，可以消除像差对散射测量的影响，从而得到准确的物镜散射系数。实验验证表明，当该系统的出瞳孔径设置为4 mm和6 mm时，测量精度比消除像差影响前分别提高了至少11.9%和28.9%。在提高测量精度的同时，该系统还将设备的尺寸和制造成本保持在较低的水平，使其更适合临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical optics express BIOCHEMICAL RESEARCH METHODS-OPTICS

CiteScore

6.80

自引率

11.80%

发文量

633

审稿时长

1 months

期刊介绍： The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including: Tissue optics and spectroscopy Novel microscopies Optical coherence tomography Diffuse and fluorescence tomography Photoacoustic and multimodal imaging Molecular imaging and therapies Nanophotonic biosensing Optical biophysics/photobiology Microfluidic optical devices Vision research.