The enigmatic voyage of pneumococcal carriage: Unraveling the risk factors in pediatric populations -- A scoping review

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2025-02-21 DOI:10.1016/j.ijmmb.2025.100808

Vaishnavi Vishram Naik , Subhangini Chakraborty , Krishnamurthy Jayanna , Tushar Shaw

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引用次数: 0

Abstract

Background

Pneumococcal infections are a major cause of morbidity and mortality globally, especially among children in low- and middle-income countries (LMICs). Although considerable research has been done on the frequency of pneumococcal infections and their risk factors, there are still many unanswered questions. The objective of this study is to offer fresh perspectives through systematic literature review on the shifting prevalence of and associated risk factors for pneumococcal colonization.

Methods

A systematic search of literature from January 2012 to December 2023 was conducted using PubMed and Scopus, with keywords related to Streptococcus pneumoniae colonization and risk factors, and references were manually screened.

Results

Studies from 41 different countries are included in the evaluation, which focuses on pediatrics patients who are most vulnerable to pneumococcal infections. The most frequent risk variables for pneumococcal colonization were having siblings, daycare centers, passive smoking, household characteristics, age, comorbidities, and vaccination status. The frequency of pneumococcal colonization was greatest among LMICs, which may be related to inadequate pneumococcal vaccination programs, densely populated areas, and a lack of knowledge about basic sanitation and hygiene.

Conclusion

The study emphasizes how crucial it is to monitor serotype prevalence to direct vaccination campaigns in these regions. For creating efficient pneumococcal disease prevention and control strategies, it is essential to understand the risk factors connected to pneumococcal colonization. The review highlights the value of vaccination campaigns in lowering the prevalence of pneumococcal illness, to completely understand the relationship between immunization, serotype colonization, and the risk of pneumococcal colonization, more study is required especially in LIC and LMIC region.

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来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.