{"title":"Unlocking the Potential of Repetitive Transcranial Magnetic Stimulation to Enhance Motor Function in Pediatric Cerebral Palsy: A Comprehensive Review.","authors":"Chia-Ling Chen","doi":"10.1016/j.bj.2025.100835","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cerebral Palsy (CP) poses a substantial challenge to pediatric motor function, necessitating effective rehabilitative interventions. This review focuses on the potential of Repetitive Transcranial Magnetic Stimulation (rTMS) as a therapeutic approach for pediatric CP. The context and purpose are framed within the need for novel strategies to enhance motor function in affected children.</p><p><strong>Material and methods: </strong>The study scrutinizes existing literature to assess the efficacy of rTMS in pediatric CP. Methodological details, including stimulation protocols, are explored. Statistical tests employed in the reviewed studies are outlined, providing insight into the scientific rigor applied in evaluating rTMS outcomes.</p><p><strong>Results: </strong>The main findings from the literature review highlight the positive impact of rTMS on motor function and spasticity reduction in children with CP. The synergistic effects observed when combining rTMS with conventional therapies such as physical or occupational therapy and constraint-induced movement therapy are emphasized.</p><p><strong>Conclusions: </strong>Evidences from literature review affirm that rTMS yields constructive outcomes, encompassing enhanced motor function and diminished spasticity, especially when combined with therapies like physical or occupational therapy, and constraint-induced movement therapy. Nevertheless, optimizing rTMS necessitates further fine-tuning of stimulation parameters. Ethical considerations and adherence to safety guidelines are crucial in pediatric settings, despite rare and typically benign side effects. Future research should focus on larger samples, stringent research designs, and long-term follow-ups to rTMS as an effective therapy for managing motor impediments in children with CP.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100835"},"PeriodicalIF":4.1000,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.bj.2025.100835","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Cerebral Palsy (CP) poses a substantial challenge to pediatric motor function, necessitating effective rehabilitative interventions. This review focuses on the potential of Repetitive Transcranial Magnetic Stimulation (rTMS) as a therapeutic approach for pediatric CP. The context and purpose are framed within the need for novel strategies to enhance motor function in affected children.
Material and methods: The study scrutinizes existing literature to assess the efficacy of rTMS in pediatric CP. Methodological details, including stimulation protocols, are explored. Statistical tests employed in the reviewed studies are outlined, providing insight into the scientific rigor applied in evaluating rTMS outcomes.
Results: The main findings from the literature review highlight the positive impact of rTMS on motor function and spasticity reduction in children with CP. The synergistic effects observed when combining rTMS with conventional therapies such as physical or occupational therapy and constraint-induced movement therapy are emphasized.
Conclusions: Evidences from literature review affirm that rTMS yields constructive outcomes, encompassing enhanced motor function and diminished spasticity, especially when combined with therapies like physical or occupational therapy, and constraint-induced movement therapy. Nevertheless, optimizing rTMS necessitates further fine-tuning of stimulation parameters. Ethical considerations and adherence to safety guidelines are crucial in pediatric settings, despite rare and typically benign side effects. Future research should focus on larger samples, stringent research designs, and long-term follow-ups to rTMS as an effective therapy for managing motor impediments in children with CP.
期刊介绍:
Biomedical Journal publishes 6 peer-reviewed issues per year in all fields of clinical and biomedical sciences for an internationally diverse authorship. Unlike most open access journals, which are free to readers but not authors, Biomedical Journal does not charge for subscription, submission, processing or publication of manuscripts, nor for color reproduction of photographs.
Clinical studies, accounts of clinical trials, biomarker studies, and characterization of human pathogens are within the scope of the journal, as well as basic studies in model species such as Escherichia coli, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus revealing the function of molecules, cells, and tissues relevant for human health. However, articles on other species can be published if they contribute to our understanding of basic mechanisms of biology.
A highly-cited international editorial board assures timely publication of manuscripts. Reviews on recent progress in biomedical sciences are commissioned by the editors.