The Interplay Between Viral Infection and Cell Death: A Ping-Pong Effect.

IF 1.1 Q4 VIROLOGY
Advances in Virology Pub Date : 2025-02-03 eCollection Date: 2025-01-01 DOI:10.1155/av/5750575
Alireza Nourazarian, Hadi Yousefi, Cigir Biray Avci, Behrouz Shademan, Emad Behboudi
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引用次数: 0

Abstract

Programmed cell death (PCD) is a well-studied cellular mechanism that plays a critical role in immune responses, developmental processes, and the maintenance of tissue homeostasis. However, viruses have developed diverse strategies to bypass or manipulate the host apoptotic machinery to enhance their replication and survival. As a result, the interaction between PCD pathways and viruses has garnered increased interest, leading to many studies being published in recent years. This study aims to provide an overview of the current understanding of PCD pathways and their significance in viral infections. We will discuss various forms of cell death pathways, including apoptosis, autophagy, necroptosis, and pyroptosis, as well as their corresponding molecular mechanisms. In addition, we will show how viruses manipulate host PCD pathways to prevent or delay cell death or facilitate viral replication. This study emphasizes the importance of investigating the mechanisms by which viruses control the host's PCD machinery to gain insight into the evolutionary dynamics of host-pathogen interactions and to develop new approaches for predicting and managing viral threats. Overall, we aimed to highlight new research areas in PCD and viruses, including introduction of new targets for the development of new antiviral drugs to modulate the cellular apoptotic machinery and novel inhibitors of host cell death pathways.

病毒感染和细胞死亡之间的相互作用:乒乓效应。
程序性细胞死亡(PCD)是一种被广泛研究的细胞机制,在免疫应答、发育过程和组织稳态维持中起着关键作用。然而,病毒已经发展出多种策略来绕过或操纵宿主凋亡机制,以增强其复制和存活。因此,PCD途径与病毒之间的相互作用引起了越来越多的兴趣,导致近年来发表了许多研究。本研究旨在概述目前对PCD途径的理解及其在病毒感染中的意义。我们将讨论各种形式的细胞死亡途径,包括凋亡、自噬、坏死坏死和焦亡,以及它们相应的分子机制。此外,我们将展示病毒如何操纵宿主PCD途径来防止或延迟细胞死亡或促进病毒复制。本研究强调了研究病毒控制宿主PCD机制的重要性,以深入了解宿主-病原体相互作用的进化动力学,并开发预测和管理病毒威胁的新方法。总的来说,我们的目标是突出PCD和病毒的新研究领域,包括引入新的靶点,开发新的抗病毒药物来调节细胞凋亡机制和宿主细胞死亡途径的新抑制剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.30
自引率
0.00%
发文量
23
审稿时长
22 weeks
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