{"title":"Oncocytic Tumors in the Thyroid: A Tri-Focal Review- Integrated Cytopathological, Pathological, and Molecular Perspectives.","authors":"Maria A Gubbiotti, Sule Canberk, Zubair W Baloch","doi":"10.1159/000544739","DOIUrl":null,"url":null,"abstract":"<p><p>Background The thyroid gland is a treasure trove of pathology ranging from the benign to the overtly malignant. Both neoplastic and non-neoplastic thyroid lesions can exhibit oncocytic change. Here we present an overview of cytologic, and histopathologic findings encountered in these oncocytic neoplasms with a focus on the molecular aspects that drive their tumorigenesis. Summary Oncocytic change is unique to a subset of thyroid lesions ranging from non-neoplastic nodular hyperplasia to high-grade malignancy. It can also be encountered in non-follicular derived neoplasms as well as in the adjacent parathyroid glands. At the genetic level, these lesions demonstrate a different genetic signature from classic follicular-derived lesions, often involving alterations of mitochondrial genes.</p>","PeriodicalId":6959,"journal":{"name":"Acta Cytologica","volume":" ","pages":"1-31"},"PeriodicalIF":1.6000,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Cytologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000544739","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background The thyroid gland is a treasure trove of pathology ranging from the benign to the overtly malignant. Both neoplastic and non-neoplastic thyroid lesions can exhibit oncocytic change. Here we present an overview of cytologic, and histopathologic findings encountered in these oncocytic neoplasms with a focus on the molecular aspects that drive their tumorigenesis. Summary Oncocytic change is unique to a subset of thyroid lesions ranging from non-neoplastic nodular hyperplasia to high-grade malignancy. It can also be encountered in non-follicular derived neoplasms as well as in the adjacent parathyroid glands. At the genetic level, these lesions demonstrate a different genetic signature from classic follicular-derived lesions, often involving alterations of mitochondrial genes.
期刊介绍：
With articles offering an excellent balance between clinical cytology and cytopathology, ''Acta Cytologica'' fosters the understanding of the pathogenetic mechanisms behind cytomorphology and thus facilitates the translation of frontline research into clinical practice. As the official journal of the International Academy of Cytology and affiliated to over 50 national cytology societies around the world, ''Acta Cytologica'' evaluates new and existing diagnostic applications of scientific advances as well as their clinical correlations. Original papers, review articles, meta-analyses, novel insights from clinical practice, and letters to the editor cover topics from diagnostic cytopathology, gynecologic and non-gynecologic cytopathology to fine needle aspiration, molecular techniques and their diagnostic applications. As the perfect reference for practical use, ''Acta Cytologica'' addresses a multidisciplinary audience practicing clinical cytopathology, cell biology, oncology, interventional radiology, otorhinolaryngology, gastroenterology, urology, pulmonology and preventive medicine.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
