Hydrodynamic Influences on Dissolution Testing Using Flow Channel Apparatuses

Abstract

The extent and rate of solution formation are measured via dissolution testing. Contrary to expectations, the intrinsic dissolution rate (IDR) is not size-independent, despite normalization of the sample area. By comparing different channel designs and sample diameters, the dimensionless boundary layer normalization factor (BNF) was developed to account for the size-dependence discovered. With the derived velocity of the boundary (v_b), the comparability of dissolution data generated with flow channel apparatuses was established, depending on the flow pattern under laminar flow conditions.