Hemodynamics of asymmetrically stenotic vertebral arteries based on fluid–solid coupling

IF 1.8 4区 生物学 Q3 BIOPHYSICS
Zheng Yilin, Feng Haiquan, He Chen, Su Juan
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引用次数: 0

Abstract

The study investigates the interaction between vertebral artery stenosis and pulsatile blood flow, with a focus on the mechanical properties and internal dynamics of blood flow. First, an asymmetrical stenosis mathematical model was established to reveal the relationship between the resistance ratio and shear stress ratio and their dependence on stenosis height and length. Next, various stenosis models were constructed using medical imaging data and analyzed through computational fluid dynamics (CFD) and fluid–structure interaction (FSI) methods. Finally, hemodynamic parameters, such as blood flow velocity and time-averaged wall shear stress (TAWSS), along with solid mechanics indicators, including total deformation and von Mises stress, were evaluated. The results indicate that changes in stenosis length and height significantly affect the resistance ratio and shear stress. Whole-segment stenosis in the vertebral artery may lead to thrombosis and intimal damage. In contrast, stenosis at the ostium of the vertebral artery increases the risk of platelet deposition on the vessel wall, potentially triggering atherosclerosis. This could ultimately lead to insufficient blood flow to the brain due to impaired vertebral artery circulation. FSI simulations revealed that elastic vessel walls are more sensitive to high-velocity flows, especially in stenotic and downstream regions. These findings provide critical insights into the effects of stenosis on blood flow and are crucial for developing effective clinical intervention strategies.

Abstract Image

基于流固耦合的不对称狭窄椎动脉血流动力学
本研究探讨了椎动脉狭窄与搏动血流之间的相互作用,重点研究了血流的力学特性和内部动力学。首先,建立了不对称狭窄数学模型,揭示了阻力比和剪应力比与狭窄高度和狭窄长度的关系;其次,利用医学影像数据构建各种狭窄模型,并通过计算流体力学(CFD)和流固耦合(FSI)方法进行分析。最后,评估血流动力学参数,如血流速度和时间平均壁剪切应力(TAWSS),以及固体力学指标,包括总变形和von Mises应力。结果表明,管腔长度和管腔高度的变化对管腔的阻力比和剪应力有显著影响。椎动脉全节段狭窄可导致血栓形成和内膜损伤。相反,椎动脉开口狭窄会增加血小板在血管壁上沉积的风险,可能引发动脉粥样硬化。这可能最终导致由于椎动脉循环受损而导致脑部供血不足。FSI模拟表明,弹性血管壁对高速流动更为敏感,特别是在狭窄和下游区域。这些发现为狭窄对血流的影响提供了重要的见解,对于制定有效的临床干预策略至关重要。
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来源期刊
Journal of Biological Physics
Journal of Biological Physics 生物-生物物理
CiteScore
3.00
自引率
5.60%
发文量
20
审稿时长
>12 weeks
期刊介绍: Many physicists are turning their attention to domains that were not traditionally part of physics and are applying the sophisticated tools of theoretical, computational and experimental physics to investigate biological processes, systems and materials. The Journal of Biological Physics provides a medium where this growing community of scientists can publish its results and discuss its aims and methods. It welcomes papers which use the tools of physics in an innovative way to study biological problems, as well as research aimed at providing a better understanding of the physical principles underlying biological processes.
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