Simple and disposable device based on gold nanoparticles modified screen-printed carbon electrode for detection of ciprofloxacin

IF 2.6 4区化学 Q3 ELECTROCHEMISTRY

Journal of Solid State Electrochemistry Pub Date : 2024-10-28 DOI:10.1007/s10008-024-06119-7

Daniela Nunes da Silva, Thaís Cristina de Oliveira Cândido, Arnaldo César Pereira

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Abstract

This study describes the development and characterization of an electrochemical sensor based on gold nanoparticles (AuNPs) immobilized on a screen-printed carbon electrode (SPCE) supported by polyethylene terephthalate (PET) for ciprofloxacin (CPX) detection. The SPCE-AuNPs sensor was fabricated using optimized carbonaceous material-based inks for the working and counter electrodes, while silver/silver chloride ink was employed for the quasi-reference electrode. Electrochemical characterization revealed a significant 223% increase in CPX oxidation current intensity compared to the unmodified SPCE electrode. Electrochemical impedance spectroscopy (EIS) confirmed this improvement, showing a decrease in charge transfer resistance (Rct) from 0.225 kΩ for SPCE to 0.125 kΩ for SPCE-AuNPs. Under optimized conditions utilizing differential pulse voltammetry (DPV), the sensor exhibited a linear range of 0.4 to 88.0 μmol L⁻¹, a limit of detection of 0.12 μmol L⁻¹, and a limit of quantification of 0.4 μmol L⁻¹. The developed method was applied to determine CPX in water and pharmaceutical formulation samples, achieving excellent recovery values ranging from 96 to 104%.

Graphical Abstract

Abstract Image

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基于金纳米颗粒修饰网印碳电极的简易一次性环丙沙星检测装置

本研究描述了一种基于金纳米颗粒（AuNPs）固定在聚对苯二甲酸乙二醇酯（PET）负载的丝网印刷碳电极（SPCE）上的用于检测环丙沙星（CPX）的电化学传感器的开发和表征。SPCE-AuNPs传感器的工作电极和反电极采用优化后的碳质材料基油墨，准参比电极采用银/氯化银油墨。电化学表征表明，与未修饰的SPCE电极相比，CPX氧化电流强度显著增加223%。电化学阻抗谱（EIS）证实了这一改进，表明SPCE的电荷转移电阻（Rct）从0.225 kΩ降至0.125 kΩ。在差分脉冲伏安法（DPV）优化条件下，传感器的线性范围为0.4 ~ 88.0 μmol L−1，检测限为0.12 μmol L−1，定量限为0.4 μmol L−1。该方法可用于水和制剂样品中CPX的测定，回收率为96% ~ 104%。图形抽象

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来源期刊

Journal of Solid State Electrochemistry 工程技术-电化学

CiteScore

4.80

自引率

4.00%

发文量

227

审稿时长

4.1 months

期刊介绍： The Journal of Solid State Electrochemistry is devoted to all aspects of solid-state chemistry and solid-state physics in electrochemistry. The Journal of Solid State Electrochemistry publishes papers on all aspects of electrochemistry of solid compounds, including experimental and theoretical, basic and applied work. It equally publishes papers on the thermodynamics and kinetics of electrochemical reactions if at least one actively participating phase is solid. Also of interest are articles on the transport of ions and electrons in solids whenever these processes are relevant to electrochemical reactions and on the use of solid-state electrochemical reactions in the analysis of solids and their surfaces. The journal covers solid-state electrochemistry and focusses on the following fields: mechanisms of solid-state electrochemical reactions, semiconductor electrochemistry, electrochemical batteries, accumulators and fuel cells, electrochemical mineral leaching, galvanic metal plating, electrochemical potential memory devices, solid-state electrochemical sensors, ion and electron transport in solid materials and polymers, electrocatalysis, photoelectrochemistry, corrosion of solid materials, solid-state electroanalysis, electrochemical machining of materials, electrochromism and electrochromic devices, new electrochemical solid-state synthesis. The Journal of Solid State Electrochemistry makes the professional in research and industry aware of this swift progress and its importance for future developments and success in the above-mentioned fields.