Highly efficient synthesis of furan-2-ylmethylboranes by a copper-catalyzed three-component cascade strategy†

Abstract

The copper-catalyzed three-component Knoevenagel condensation/enynone cyclization/B–H bond insertion cascade offers a concise and highly efficient one-step access to furan-2-ylmethylboranes. This protocol has broad substrate scope and good functional group compatibility. Its synthetic practicability is demonstrated by a large-scale experiment and the application to facile one-pot synthesis of masked boronic acids.