Comparison of dose distribution with and without reflecting heterogeneous boron distribution using 18F-BPA positron emission tomography in boron neutron capture therapy

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2025-02-13 DOI:10.1016/j.apradiso.2025.111720

Yuta Kobayashi , Satoshi Nakamura , Mihiro Takemori , Tetsu Nakaichi , Yasunori Shuto , Kimiteru Ito , Kana Takahashi , Tairo Kashihara , Miki Yonemura , Hana Endo , Kouji Kunito , Hiroyuki Okamoto , Takahito Chiba , Hiroki Nakayama , Riki Oshika , Hironori Kishida , Jun Itami , Hiroaki Kurihara , Hiroshi Igaki

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Abstract

This study investigated the dosimetric impact of implementing heterogeneous boron distribution into dose evaluations on tumors in BNCT. The study involved 27 patients who underwent ¹⁸F-BPA PET/CT scans. Dose evaluations were performed using various methods reflecting boron concentrations on CT images. The conventional dose evaluations, which reflected uniform boron concentration in blood of 25 ppm and a constant tumor-to-blood (T/B) ratio of 3.5, were compared with individual dose evaluations, which reflected the blood boron concentration and T/B ratio calculated from ¹⁸F-BPA in each patient. The heterogeneous tumoral dose distribution was also compared, revealing the dosimetric impact of the boron distribution calculated from each voxel of ¹⁸F-BPA. The spatial correspondence between ¹⁸F-BPA and dose distribution was compared using metabolic tumor volume (MTV) from ¹⁸F-BPA and isodose volume from the heterogeneous dose distribution. Results showed that the median blood boron concentration and T/B ratio calculated from ¹⁸F-BPA were 25.57 (23.90–27.84) ppm and 3.75 (2.54–4.59), respectively, comparable to those in the conventional dose evaluations. All dose indices in the heterogeneous tumoral dose evaluations were significantly lower than those in the conventional dose evaluations (p < 0.01). However, the spatial correspondence between the ¹⁸F-BPA and the dose distribution was not observed in the dice similarity coefficients of both MTV40-40% isodose volume and MTV50-50% isodose volume. In conclusion, the study confirmed the validity of applying the boron concentration calculated from ¹⁸F-BPA to the dose evaluation for a patient in BNCT. The differences might be associated with non-inter-patient variations of ¹⁸F-BPA, but the conventional dose evaluations mainly focused on the high boron concentration area within the tumor. Furthermore, the discrepancies in the patients were also observed between the ¹⁸F-BPA distribution and the heterogeneous dose distribution. Therefore, this study suggested that the indications for BNCT should consider not only ¹⁸F-BPA but also the dose distributions, which could reflect the heterogeneous tumoral boron distribution.

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.