The impact of dry eye disease on patient-reported quality of life: A Save Sight Dry Eye Registry study

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface Pub Date : 2025-02-13 DOI:10.1016/j.jtos.2025.02.005

Himal Kandel , Fiona Stapleton AO , Laura E. Downie , Ngozi C Chidi‐Egboka , David MIngo-Botin , Francisco Arnalich-Montiel , Saaeha Rauz , Alberto Recchioni , Sanjeeta Sitaula , Maria Markoulli , Vincent Daien , Fanny Babeau , Gerd Geerling , Jennifer P. Craig , Stephanie L. Watson OAM

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引用次数: 0

Abstract

Purpose

The aim of this real-world registry study was to evaluate the quality-of-life (QoL) impact of dry eye disease (DED). The specific objectives were to determine factors affecting QoL in DED, and to evaluate the psychometric properties of the Ocular Surface Disease Index (OSDI), Ocular Comfort Index (OCI), and Patient Health Questionnaire (PHQ) in a real-world DED population using modern psychometric methods.

Methods

This descriptive cross-sectional study included 368 DED patients (mean 54.7 ± 16.6 years; 80.2 % female) who completed one or more of the three questionnaires (OSDI, OCI and PHQ). Psychometric analysis of the QoL data was carried out with Andrich's Rating Scale Model of Rasch analysis.

Results

The original OSDI and OCI had disordered categories. The Rasch-optimised final QoL scales (OSDI – Overall, OSDI – Symptoms [SY], OSDI – Activity limitation [AL], OSDI – Environmental trigger [EN], OCI Overall, OCI - Frequency [FR], OCI - Intensity [IN], and PHQ) had satisfactory psychometric properties. Patients diagnosed with a mixed aqueous/evaporative DED subtype had worse mean OSDI-Overall and OSDI-AL scores than individuals with evaporative DED (p = 0.012 and 0.001 respectively). Patients with corneal neuropathic pain had worse QoL scores (OSDI-Overall, OSDI-AL, OSDI-SY, OSDI-EN, OCI-Overall, OCI-FR, OCI-IN, and PHQ; all p < 0.05) than those without. Patients who reported undergoing prior treatment or procedure for DED had worse QoL scores than those who did not (all p < 0.05 except for PHQ). The associations between DED signs (tear breakup time and staining) and symptoms were weak or not significant.

Conclusions

In this real-world setting, diagnoses of mixed DED, corneal neuropathic pain, and history of DED treatment/procedures were associated with worse dry eye symptoms, activity limitation, and/or QoL.

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干眼病对患者报告的生活质量的影响：一项拯救视力干眼症登记研究。

目的：本研究的目的是评估干眼病（DED）对生活质量（QoL）的影响。具体目的是确定影响DED患者生活质量的因素，并使用现代心理测量方法评估现实世界DED人群的眼表疾病指数（OSDI）、眼舒适度指数（OCI）和患者健康问卷（PHQ）的心理测量特性。方法：本描述性横断面研究纳入368例DED患者(平均54.7±16.6岁；80.2%女性)，完成三项问卷（OSDI、OCI和PHQ）中的一项或多项。生活质量数据采用Rasch分析的Andrich评定量表模型进行心理测量分析。结果：原始OSDI和OCI有紊乱分类。rasch优化的最终生活质量量表（OSDI - Overall, OSDI - symptom [SY], OSDI - Activity limitation [AL], OSDI - Environmental trigger [EN], OCI Overall, OCI- frequency [FR], OCI- intensity [IN] and PHQ）具有令人满意的心理测量特性。诊断为水/蒸发性DED混合亚型的患者的平均OSDI-Overall评分和OSDI-AL评分低于蒸发性DED个体（p分别= 0.012和0.001）。角膜神经性疼痛患者的生活质量评分较差(OSDI-Overall、OSDI-AL、OSDI-SY、OSDI-EN、OCI-Overall、OCI-FR、OCI-IN和PHQ；p < 0.05)。先前接受过DED治疗或手术的患者的生活质量评分比未接受治疗的患者差（除PHQ外，所有p < 0.05）。DED体征（泪液破裂时间和染色）与症状之间的相关性较弱或不显著。结论：在现实世界中，混合性DED的诊断、角膜神经性疼痛和DED治疗/手术史与更严重的干眼症状、活动限制和/或生活质量相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Surface 医学-眼科学

CiteScore

11.60

自引率

14.10%

发文量

审稿时长

39 days

期刊介绍： The Ocular Surface, a quarterly, a peer-reviewed journal, is an authoritative resource that integrates and interprets major findings in diverse fields related to the ocular surface, including ophthalmology, optometry, genetics, molecular biology, pharmacology, immunology, infectious disease, and epidemiology. Its critical review articles cover the most current knowledge on medical and surgical management of ocular surface pathology, new understandings of ocular surface physiology, the meaning of recent discoveries on how the ocular surface responds to injury and disease, and updates on drug and device development. The journal also publishes select original research reports and articles describing cutting-edge techniques and technology in the field. Benefits to authors We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services. Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our Support Center