Incidence of RSV-related hospitalizations for ARIs, including CAP: Data from the German prospective ThEpiCAP study

IF 14.3 1区医学 Q1 INFECTIOUS DISEASES

Journal of Infection Pub Date : 2025-02-12 DOI:10.1016/j.jinf.2025.106440

Caihua Liang , Elizabeth Begier , Stefan Hagel , Juliane Ankert , Liz Wang , Claudia Schwarz , Lea J. Bayer , Christof von Eiff , Qing Liu , Jo Southern , Jeffrey Vietri , Sonal Uppal , Bradford D. Gessner , Christian Theilacker , Mathias W. Pletz

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引用次数: 0

Abstract

Background

RSV is a leading cause of ARI, including CAP, in older adults. Data available often underestimate RSV-related ARI incidence. We estimated RSV-related ARI hospitalization incidence from a prospective CAP study, adjusting for undiagnosed RSV infections due to nasopharyngeal/nasal swab testing only.

Methods

Active surveillance of adult CAP hospitalizations in Germany was conducted between 2021–2023. Nasopharyngeal/nasal swabs were RSV-tested, and age-group specific proportions were applied to calculate RSV-related CAP incidence. This was divided by the CAP proportions among RSV-related ARI hospitalizations (from multispecimen study) to extrapolate RSV-related ARI rates.

Results

Among 1040 radiologically confirmed CAP cases, 3.7% tested RSV-positive via nasopharyngeal/nasal swab, corresponding to 7.8% after adjusting for underdetection. For 18–59 and ≥60 years, adjusted RSV-related CAP hospitalization rates (95% CI) were 4.9 (1.8–10.9) and 115.6 (78.8–163.6); adjusted RSV-related ARI hospitalization rates were 19.8 (6.8–50.1) and 401.6 (260.7–609.3) per 100,000, respectively. Within 30 days of an RSV-related CAP admission, 18.2% of those ≥65 years died, and 11.1% and 36.4% had cardiovascular events among those 18–64 and ≥65 years, respectively.

Conclusions

Older adults in Germany experience a high burden of RSV-related ARI hospitalizations, including CAP, underscoring RSV vaccination’s potential utility for this population.

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来源期刊

Journal of Infection 医学-传染病学

CiteScore

45.90

自引率

3.20%

发文量

475

审稿时长

16 days

期刊介绍： The Journal of Infection publishes original papers on all aspects of infection - clinical, microbiological and epidemiological. The Journal seeks to bring together knowledge from all specialties involved in infection research and clinical practice, and present the best work in the ever-changing field of infection. Each issue brings you Editorials that describe current or controversial topics of interest, high quality Reviews to keep you in touch with the latest developments in specific fields of interest, an Epidemiology section reporting studies in the hospital and the general community, and a lively correspondence section.