{"title":"Oral side effects of fluoxetine in patients with depressive disorder: A systematic review.","authors":"M-G Sarrión Pérez, Y Jiménez, L Bagan, J Bagan","doi":"10.4317/medoral.26947","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Selective serotonin reuptake inhibitors are currently the preferred drugs for treating depression, a condition that has become more prevalent in recent years. Fluoxetine is one of the most widely used, but, like other antidepressants, it can cause several systemic and oral adverse effects. This systematic review aimed to analyze the frequency of oral adverse effects of fluoxetine in comparison to other antidepressants.</p><p><strong>Material and methods: </strong>A systematic review was conducted following PRISMA guidelines. A comprehensive literature search was performed in MEDLINE via PubMed, Scopus, The Cochrane Library, and Web of Science, with no date restrictions, including randomized clinical trials and observational studies. The risk of bias was assessed using the Revised Cochrane Risk-of-Bias Tool for randomized trials.</p><p><strong>Results: </strong>A total of 333 articles were identified. After removing duplicates and applying inclusion criteria, 31 randomized clinical trials were selected for analysis. Fluoxetine was primarily compared with tricyclic antidepressants, SSRIs, serotonin-norepinephrine reuptake inhibitors, and other antidepressants. The most frequently reported oral side effect was dry mouth, with prevalence rates ranging from 2.71% to 52.17%, though it was generally lower than with other antidepressants. Dysgeusia was less frequently reported, with only two studies documenting taste alterations. Oral side effects were primarily assessed through subjective patient reports, and no studies incorporated objective salivary flow measurements. Other adverse effects, such as nausea and vomiting, were commonly mentioned, but their potential oral consequences were not evaluated.</p><p><strong>Conclusions: </strong>Fluoxetine is associated with oral side effects, with dry mouth being the most frequently reported. However, data on dysgeusia remain limited, highlighting the need for further research to determine its prevalence. Given the potential impact of dry mouth on oral health and quality of life, future studies should incorporate objective salivary measurements and further investigate the clinical implications of these adverse effects.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina Oral Patologia Oral Y Cirugia Bucal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4317/medoral.26947","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Selective serotonin reuptake inhibitors are currently the preferred drugs for treating depression, a condition that has become more prevalent in recent years. Fluoxetine is one of the most widely used, but, like other antidepressants, it can cause several systemic and oral adverse effects. This systematic review aimed to analyze the frequency of oral adverse effects of fluoxetine in comparison to other antidepressants.
Material and methods: A systematic review was conducted following PRISMA guidelines. A comprehensive literature search was performed in MEDLINE via PubMed, Scopus, The Cochrane Library, and Web of Science, with no date restrictions, including randomized clinical trials and observational studies. The risk of bias was assessed using the Revised Cochrane Risk-of-Bias Tool for randomized trials.
Results: A total of 333 articles were identified. After removing duplicates and applying inclusion criteria, 31 randomized clinical trials were selected for analysis. Fluoxetine was primarily compared with tricyclic antidepressants, SSRIs, serotonin-norepinephrine reuptake inhibitors, and other antidepressants. The most frequently reported oral side effect was dry mouth, with prevalence rates ranging from 2.71% to 52.17%, though it was generally lower than with other antidepressants. Dysgeusia was less frequently reported, with only two studies documenting taste alterations. Oral side effects were primarily assessed through subjective patient reports, and no studies incorporated objective salivary flow measurements. Other adverse effects, such as nausea and vomiting, were commonly mentioned, but their potential oral consequences were not evaluated.
Conclusions: Fluoxetine is associated with oral side effects, with dry mouth being the most frequently reported. However, data on dysgeusia remain limited, highlighting the need for further research to determine its prevalence. Given the potential impact of dry mouth on oral health and quality of life, future studies should incorporate objective salivary measurements and further investigate the clinical implications of these adverse effects.
背景:选择性血清素再摄取抑制剂是目前治疗抑郁症的首选药物,近年来抑郁症变得越来越普遍。氟西汀是使用最广泛的抗抑郁药之一,但是,像其他抗抑郁药一样,它会引起一些全身和口服不良反应。本系统综述旨在分析氟西汀与其他抗抑郁药相比口服不良反应的频率。材料和方法:为此,在Medline、Scopus、Cochrane和Web of Science数据库中进行了检索,其中包括随机临床试验和观察性研究。结果:共收集文献333篇。排除重复后,不符合纳入标准的文章被丢弃,最终入选31项研究。结论:口干是氟西汀最常见的口腔不良反应,发生率为2.71% ~ 52.17%。然而,与其他抗抑郁药相比,它的发生率较低。目前尚不清楚这种感觉是否伴随着唾液流量减少,因为研究没有进行客观的确定。关于阅读障碍,由于只有两篇文章收集了相关数据,因此无法分析其频率。所选文章还提到了其他不良反应,如恶心或呕吐。然而,没有一项研究评估这些影响可能导致的口腔症状。
期刊介绍:
1. Oral Medicine and Pathology:
Clinicopathological as well as medical or surgical management aspects of
diseases affecting oral mucosa, salivary glands, maxillary bones, as well as
orofacial neurological disorders, and systemic conditions with an impact on
the oral cavity.
2. Oral Surgery:
Surgical management aspects of diseases affecting oral mucosa, salivary glands,
maxillary bones, teeth, implants, oral surgical procedures. Surgical management
of diseases affecting head and neck areas.
3. Medically compromised patients in Dentistry:
Articles discussing medical problems in Odontology will also be included, with
a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients.
4. Implantology
5. Periodontology