Dysregulation of amino acid and lipid metabolism in patients with spondyloarthritis.

IF 1.4 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of International Medical Research Pub Date : 2025-02-01 DOI:10.1177/03000605251313949

Constantin Remus, Meike Hoffmeister, Selina Strathmeyer, Steffen Heelemann, Inga Claus, Werner Dammermann, Oliver Ritter, Daniel Patschan, Susann Patschan

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引用次数: 0

Abstract

Objective: To conduct a metabolomics analysis in patients with spondyloarthritis (SpA) and compare results with those from healthy controls. The overall goal was to identify small-molecule substances that may have potential pathogenic and diagnostic significance in SpA.

Methods: This was an observational, cross-sectional, single-centre study that included patients with axial (ankylosing spondylitis [AS]), peripheral (psoriatic arthritis [PsA]) and healthy controls.

Results: The study included 50 patients with AS, 50 patients with PsA, and 164 controls. When compared with healthy controls, patients with SpA showed significant differences in 35 metabolites, primarily associated with amino acid and lipid metabolism. However, only two differences were found between the AS and PsA cohorts (glucose and glycerol).

Conclusions: Our data suggest that patients with SpA exhibit significant disruptions in amino acid and lipid metabolism. The large number of identified metabolites offers promising opportunities, both for discovering new SpA biomarkers and for gaining a deeper understanding of the pathophysiology of these chronic inflammatory diseases.

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脊椎关节炎患者的氨基酸和脂质代谢失调。

目的：对脊椎关节炎（SpA）患者进行代谢组学分析，并将结果与健康对照组进行比较。总体目标是鉴定可能在SpA中具有潜在致病和诊断意义的小分子物质。方法：这是一项观察性、横断面、单中心研究，包括轴向（强直性脊柱炎[AS]）、外周（银屑病关节炎[PsA]）患者和健康对照。结果：该研究包括50例AS患者，50例PsA患者和164例对照。与健康对照组相比，SpA患者在35种代谢物中表现出显著差异，主要与氨基酸和脂质代谢相关。然而，在AS组和PsA组之间只发现两个差异（葡萄糖和甘油）。结论：我们的数据表明，SpA患者在氨基酸和脂质代谢方面表现出明显的破坏。大量已鉴定的代谢物为发现新的SpA生物标志物和深入了解这些慢性炎症性疾病的病理生理学提供了有希望的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of International Medical Research 医学-药学

CiteScore

3.20

自引率

0.00%

发文量

555

审稿时长

1 months

期刊介绍： _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605