Anti-inflammatory lignans from peeled stems of Syringa pinnatifolia

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-02-13 DOI:10.1016/j.fitote.2025.106445

Hongying Chen , Jiatong Wang , Jingjing Sun , Qiuyuan Ding , Yiru Shen , Tao Wang , Changxin Liu , Xiaoli Gao , Xingyun Chai

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引用次数: 0

Abstract

Three new lignans namely alashanenols H₁–J₁ (1–3) and one dimeric lignan namely bisyringol A (4) together with 15 known analogues (5–19) were isolated from the peeled stems of Syringa pinnatifolia Hemsl. with the aid of an in vitro anti-inflammation guided fractionation. The structures were elucidated by analysis of spectroscopic data, including IR, UV, MS, and NMR, and their absolute configurations were resolved by X-ray single crystal diffraction analysis and comparison of experimental and calculated ¹³C NMR and ECD data. Compound 2 possesses a cage-like motif in lignan family and 4 owns a rare framework composed of one lignan and one norlignan fragments. The bioassay results showed that 4, 13, and 18 significantly inhibit the NO production in LPS-induced RAW264.7 cells with IC₅₀ values of 5.90 ± 0.28, 53.26 ± 9.96 and 53.25 ± 6.84 μM, compared with the positive control indomethacin (IC₅₀ 33.6).

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.