Advancements in pharmacological interventions for atopic dermatitis current strategies and future directions.

IF 4.6 2区 医学 Q2 IMMUNOLOGY
Inflammopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-15 DOI:10.1007/s10787-025-01659-4
Yan Zhang, Shaoying Yuan, Yixing Wu, Wenkai Nie, Tianhui You, Huiwen Yang, Bing Liu
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引用次数: 0

Abstract

Atopic dermatitis (AD) is a complex chronic inflammatory skin disorder, with its incidence significantly increasing in recent years. The pathogenesis of AD is complex, involving multiple factors such as genetic susceptibility, dysbiosis of the skin microbiome, autoimmune abnormalities, impaired epidermal barrier function, and environmental factors. These factors collectively contribute to the high incidence of the disease and its significant socio-economic burden. This article reviews the pathogenesis of AD and analyzes the current traditional treatment approaches, including topical and systemic therapies, highlighting the issues they face. It focuses on the current status and treatment strategies. Specifically, as the significant heterogeneity of AD, treatment paradigms are gradually shifting from a "one-size-fits-all" approach to personalized treatments. The aim is to achieve more effective management of AD and address the issues arising from individual differences. Through these discussions, this article aims to provide new perspectives and strategies for the clinical treatment of AD, in order to reduce the disease burden on patients.

特应性皮炎的药物干预研究进展:当前策略和未来方向。
特应性皮炎(AD)是一种复杂的慢性炎症性皮肤病,近年来发病率显著上升。AD的发病机制复杂,涉及多种因素,如遗传易感性、皮肤微生物群失调、自身免疫异常、表皮屏障功能受损以及环境因素等。这些因素共同造成该病的高发病率及其沉重的社会经济负担。本文综述了AD的发病机制,分析了目前的传统治疗方法,包括局部治疗和全身治疗,并强调了它们面临的问题。重点介绍了目前的现状和治疗策略。具体来说,由于阿尔茨海默病的显著异质性,治疗模式正逐渐从“一刀切”转向个性化治疗。目的是实现对AD的更有效管理,并解决因个体差异而产生的问题。通过这些讨论,本文旨在为AD的临床治疗提供新的视角和策略,以减轻患者的疾病负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Inflammopharmacology
Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY
CiteScore
8.00
自引率
3.40%
发文量
200
期刊介绍: Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]
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