Triglyceride glucose-waist circumference as a predictor of mortality and subtypes of cardiovascular disease: a systematic review and meta-analysis.

IF 3.4 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetology & Metabolic Syndrome Pub Date : 2025-02-15 DOI:10.1186/s13098-025-01616-9

Mehrdad Rabiee Rad, Ghazal Ghasempour Dabaghi, Hossein Sadri, Bahar Darouei, Reza Amani-Beni, Sadegh Mazaheri-Tehrani

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引用次数: 0

Abstract

Background: The significant burden of cardiovascular diseases underscores the necessity for identifying novel predictive markers that can forecast both cardiovascular diseases and mortality. In recent years, TyG-obesity-related parameters have gained special attention in this regard. This study aimed to assess the association between TyG-waist circumference (TyG-WC) and cardiovascular diseases and mortality.

Methods: A comprehensive search was performed in databases including PubMed, Scopus, and Web of Science from their inception until October 6, 2024. The key outcomes of interest included all-cause mortality, cardiovascular mortality, cardiovascular diseases, myocardial infarction, stroke, coronary artery diseases, peripheral artery diseases, and heart failure. The pooled risk ratio (RR) with corresponding 95% confidence intervals (CI) was calculated. Meta-analysis was carried out using StataMP 14.0.

Results: A total of 17 studies were included in the analysis. The number of participants ranged between 2,224 and 95,342. The meta-analysis revealed that TyG-WC is significantly associated with an increased risk of all-cause mortality, cardiovascular mortality, cardiovascular diseases, myocardial infarction, stroke, coronary artery diseases, and peripheral artery diseases. However, only one study addressed the relationship between TyG-WC and heart failure with a positive correlation.

Conclusion: This study indicates that TyG-WC could serve as a promising predictor of cardiovascular diseases, along with cardiovascular and all-cause mortality. Given its accessibility, TyG-WC may be a practical tool for screening purposes.

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甘油三酯葡萄糖腰围作为死亡率和心血管疾病亚型的预测因子：一项系统回顾和荟萃分析

背景：心血管疾病的巨大负担强调了识别能够预测心血管疾病和死亡率的新型预测标志物的必要性。近年来，tyg肥胖相关参数在这方面得到了特别的关注。本研究旨在评估tyg腰围（TyG-WC）与心血管疾病和死亡率之间的关系。方法：对PubMed、Scopus、Web of Science等数据库进行全面检索，检索时间从其成立到2024年10月6日。主要结局包括全因死亡率、心血管死亡率、心血管疾病、心肌梗死、中风、冠状动脉疾病、外周动脉疾病和心力衰竭。计算合并风险比（RR）及相应的95%置信区间（CI）。meta分析采用StataMP 14.0进行。结果：共纳入17项研究。参与调查的人数在2224到95342人之间。荟萃分析显示，TyG-WC与全因死亡率、心血管死亡率、心血管疾病、心肌梗死、中风、冠状动脉疾病和外周动脉疾病的风险增加显著相关。然而，只有一项研究表明TyG-WC与心力衰竭呈正相关。结论：本研究提示TyG-WC可作为心血管疾病以及心血管和全因死亡率的一个有希望的预测因子。鉴于其可访问性，TyG-WC可能是用于筛选目的的实用工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

6.20

自引率

0.00%

发文量

170

审稿时长

7.5 months

期刊介绍： Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.