{"title":"What was the scientific context in which I wrote my 1975 “Inositol phospholipids and cell surface receptor function” review?","authors":"Robert H. (Bob) Michell","doi":"10.1016/j.bbalip.2025.159601","DOIUrl":null,"url":null,"abstract":"<div><div>50 years on from my BBA review, I was delighted to hear that many of the current leaders of research across “The Multiverse of Phosphoinositides” are contributing to an authoritative collection of articles on the current state of that cosmology of cell functions – and that three other inositidonauts who were launched from Birmingham are assembling it. When the phosphoinositidase C signalling pathway emerged into the cell regulation limelight during the early 1980s it drew attention to a family of metabolically atypical membrane phospholipids that most biologists had been comfortably ignoring. Looking back, it is remarkable how many important clues were already loitering in the literature, waiting for us to start to make sense of them in the 1970s.</div></div>","PeriodicalId":8815,"journal":{"name":"Biochimica et biophysica acta. Molecular and cell biology of lipids","volume":"1870 3","pages":"Article 159601"},"PeriodicalIF":3.9000,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et biophysica acta. Molecular and cell biology of lipids","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1388198125000095","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
50 years on from my BBA review, I was delighted to hear that many of the current leaders of research across “The Multiverse of Phosphoinositides” are contributing to an authoritative collection of articles on the current state of that cosmology of cell functions – and that three other inositidonauts who were launched from Birmingham are assembling it. When the phosphoinositidase C signalling pathway emerged into the cell regulation limelight during the early 1980s it drew attention to a family of metabolically atypical membrane phospholipids that most biologists had been comfortably ignoring. Looking back, it is remarkable how many important clues were already loitering in the literature, waiting for us to start to make sense of them in the 1970s.
期刊介绍:
BBA Molecular and Cell Biology of Lipids publishes papers on original research dealing with novel aspects of molecular genetics related to the lipidome, the biosynthesis of lipids, the role of lipids in cells and whole organisms, the regulation of lipid metabolism and function, and lipidomics in all organisms. Manuscripts should significantly advance the understanding of the molecular mechanisms underlying biological processes in which lipids are involved. Papers detailing novel methodology must report significant biochemical, molecular, or functional insight in the area of lipids.