Cover Feature: Design, Synthesis, and Anti-Prostate Cancer Potential of 2-(4-Nitrobenzyl) Malonates In Vitro and DAL Acute Oral Toxicity Assessment In Vivo (ChemMedChem 4/2025)
{"title":"Cover Feature: Design, Synthesis, and Anti-Prostate Cancer Potential of 2-(4-Nitrobenzyl) Malonates In Vitro and DAL Acute Oral Toxicity Assessment In Vivo (ChemMedChem 4/2025)","authors":"Bharathi Hassan Ganesh, Baladhandapani Aruchamy, Srikrishna Mudradi, Sarthak Mohanty, Himabindu Padinjarathil, Simone Carradori, Prasanna Ramani","doi":"10.1002/cmdc.202580402","DOIUrl":null,"url":null,"abstract":"<p>2-[(4-Nitrophenyl)methyl]propanedioates and 2-[(4-aminophenyl)methyl]propanedioates were synthesized with malonates and 4-nitrobenzyl bromide as starting materials. The six compounds were spectrophotometrically characterized post-purification and evaluated for their antioxidant, anti-inflammatory, and anticancer properties with a variety of assays. The most potent compound 3c was evaluated for its efficacy in vivo in a Dalton Ascites Lymphoma murine model and evaluated computationally for its apoptosis-inducing abilities. More details can be found in article 10.1002/cmdc.202400371 by Simone Carradori, Prasanna Ramani, and co-workers.<figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"20 4","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.202580402","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemMedChem","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cmdc.202580402","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
2-[(4-Nitrophenyl)methyl]propanedioates and 2-[(4-aminophenyl)methyl]propanedioates were synthesized with malonates and 4-nitrobenzyl bromide as starting materials. The six compounds were spectrophotometrically characterized post-purification and evaluated for their antioxidant, anti-inflammatory, and anticancer properties with a variety of assays. The most potent compound 3c was evaluated for its efficacy in vivo in a Dalton Ascites Lymphoma murine model and evaluated computationally for its apoptosis-inducing abilities. More details can be found in article 10.1002/cmdc.202400371 by Simone Carradori, Prasanna Ramani, and co-workers.
期刊介绍：
Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs.
Contents
ChemMedChem publishes an attractive mixture of:
Full Papers and Communications
Reviews and Minireviews
Patent Reviews
Highlights and Concepts
Book and Multimedia Reviews.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
