Investigation of Neuronal–Astroglial Injury Proteins and MMP-9 Serum Levels in Autism Spectrum Disorder and Their Relationship With Autistic Regression
Huriye Berna Devecioğlu, Çağman Tan, Ekin Günal Mısır, Halime Tuna Çak Esen, Begüm Özbek, Sadriye Ebru Çengel Kültür
{"title":"Investigation of Neuronal–Astroglial Injury Proteins and MMP-9 Serum Levels in Autism Spectrum Disorder and Their Relationship With Autistic Regression","authors":"Huriye Berna Devecioğlu, Çağman Tan, Ekin Günal Mısır, Halime Tuna Çak Esen, Begüm Özbek, Sadriye Ebru Çengel Kültür","doi":"10.1002/jdn.70005","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>This study compared serum levels of S100B, GFAP, UCHL-1, NF-H and MMP-9 between children with Autism Spectrum Disorder (ASD) and controls, focusing on their association with regression in ASD. We hypothesized that neuroinflammation and neuronal/astroglial damage markers would be higher in the ASD group than in controls and even more elevated in the regressive ASD subgroup compared to the non-regressive subgroup.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The study included 50 children with ASD (ages 4–10) and 30 healthy children. Participants underwent the K-SADS-PL diagnostic interview, CARS, a semi-structured interview for regression, ABC, AuBC, CPRS-RS and SRS assessments. Serum levels of S100B, GFAP, UCHL-1, NF-H and MMP-9 were measured using flow cytometry and ELISA.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Serum levels of S100B, GFAP, UCHL-1, NF-H and MMP-9 showed no significant differences between the ASD and control groups. Within the ASD group, no notable differences were found in sociodemographic, clinical characteristics, or serum marker levels between those with and without regression.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The findings obtained in this study suggested that it is necessary to question whether the peripheral circulation can represent changes in central nervous system and to review the existence of autistic regression as a separate entity in ASD in terms of clinical features and etiopathogenesis.</p>\n </section>\n </div>","PeriodicalId":13914,"journal":{"name":"International Journal of Developmental Neuroscience","volume":"85 1","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Developmental Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jdn.70005","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective
This study compared serum levels of S100B, GFAP, UCHL-1, NF-H and MMP-9 between children with Autism Spectrum Disorder (ASD) and controls, focusing on their association with regression in ASD. We hypothesized that neuroinflammation and neuronal/astroglial damage markers would be higher in the ASD group than in controls and even more elevated in the regressive ASD subgroup compared to the non-regressive subgroup.
Methods
The study included 50 children with ASD (ages 4–10) and 30 healthy children. Participants underwent the K-SADS-PL diagnostic interview, CARS, a semi-structured interview for regression, ABC, AuBC, CPRS-RS and SRS assessments. Serum levels of S100B, GFAP, UCHL-1, NF-H and MMP-9 were measured using flow cytometry and ELISA.
Results
Serum levels of S100B, GFAP, UCHL-1, NF-H and MMP-9 showed no significant differences between the ASD and control groups. Within the ASD group, no notable differences were found in sociodemographic, clinical characteristics, or serum marker levels between those with and without regression.
Conclusion
The findings obtained in this study suggested that it is necessary to question whether the peripheral circulation can represent changes in central nervous system and to review the existence of autistic regression as a separate entity in ASD in terms of clinical features and etiopathogenesis.
期刊介绍：
International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
