Effect of manganese doping on the bioactivity and antioxidant activity of bioglass

IF 2.5 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Applied Physics A Pub Date : 2025-02-17 DOI:10.1007/s00339-025-08343-y

Chunrong Yang, Huazhong Wu, Xiaojie Gao, Congfa Zhang

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Abstract

Manganese is an essential micronutrient for all living organisms and plays a crucial role in bone metabolism. The purpose of this study was to investigate the effects of manganese on the structure and chemical dissolution behavior of bioactive glasses, as well as its effects on in vitro biological activity and oxidative stress levels. Manganese doped bioglass was synthesized by sol-gel method. Its structure was studied using FTIR combined with Raman spectroscopy. The in vitro mineralization performance in simulated body fluids was analyzed using X-ray diffraction, FTIR and ultraviolet spectroscopy. The antioxidant capacity of manganese doped bioglass was studied using MC3T3-E1 cells against H₂O₂ induced damage. The doping of manganese caused slight changes in the bioglass structure, and enabled it to obtain crystalline phases of calcium manganese silicate and calcium silicate through calcination. All bioglass exhibited good ability to form hydroxyapatite. Compared to the parent bioglass, manganese doping significantly enhanced the dissolution and biomineralization behavior. The protective potential of manganese doped bioglass exhibited dose-dependent effects within a limited concentration range, with excellent anti-oxidant ability observed at low doses of doping. Manganese doped bioglass has potential applications in bone regeneration and healing.

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来源期刊

Applied Physics A 工程技术-材料科学：综合

CiteScore

4.80

自引率

7.40%

发文量

964

审稿时长

38 days

期刊介绍： Applied Physics A publishes experimental and theoretical investigations in applied physics as regular articles, rapid communications, and invited papers. The distinguished 30-member Board of Editors reflects the interdisciplinary approach of the journal and ensures the highest quality of peer review.