Advanced Hydrogel Dressing with Zinc Oxide-Copper Oxide Nanocomposite for Effective Wound Management: Mechanochemistry, Antibacterial Efficacy, Cytocompatibility and Wound Healing Potentials

IF 4.7 3区工程技术 Q2 ENGINEERING, ENVIRONMENTAL

Journal of Polymers and the Environment Pub Date : 2025-01-25 DOI:10.1007/s10924-024-03468-2

Nasrin K. Ramtan Gadaime, Rabiatul Basria S. M. N. Mydin, G. Ambarasan Govindasamy, Yazmin Bustami, Srimala Sreekantan

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Abstract

Managing open wounds is difficult because of the risk of bacterial infections and moisture loss, which can delay healing. Advanced wound care solutions are essential for healing. Hydrogel bandages provide a promising option because of the unique features of hydrogel such as high porosity and absorbency from its hydrophilic polymer composition. In addition, advanced hydrogel dressings infused with nanotechnology, especially zinc oxide–copper oxide (ZnO–CuO) nanocomposites, remarkably improve the effectiveness of wound care strategies. In the current study, the mechanochemistry, antibacterial efficacy, cytocompatibility and wound healing potential of ZnO–CuO nanocomposite-embedded polyethylene glycol hydrogel (CPZCH) were investigated. Antibacterial profiles were examined by disc diffusion, time-kill tests, and bacterial cell adherence against S. aureus, MRSA, P. aeruginosa and E. coli. Cytocompatibility and wound healing profiles were studied using the fibroblast cells. CPZCH exhibited favourable swelling‐shrinkable behaviours with a swelling, porosity and degradation ratio of approximately 1920.45%, 142.86% and 60.27%, respectively. These characteristics are crucial for maintaining a moist wound environment, facilitating nutrient distribution and making eco-friendly dressings. CPZCH exhibited antibacterial potential within 24h, which is crucial for managing infection and protecting wounds from bacterial infections. CPZCH exhibited high cytocompatibility (~ 110.177%) and remarkable in vitrowound healing properties within 48h, which are crucial for maintaining cell integrity from toxicity and rapid wound closure. Therefore, CPZCH showed great application potential in wound dressing with favourable swelling‐shrinkable behaviours, antibacterial efficacy, cytocompatibility and wound healing properties. Further studies especially involving hemocompatibility and molecular interaction are necessary to reach comprehensive knowledge about the behaviour of the dressing in wound management.

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来源期刊

Journal of Polymers and the Environment 工程技术-高分子科学

CiteScore

9.50

自引率

7.50%

发文量

297

审稿时长

9 months

期刊介绍： The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.