Room-Temperature Synthesis of pH-Responsive MOF Nanocarriers for Targeted Drug Delivery in Cancer Therapy

IF 4.7 3区工程技术 Q2 ENGINEERING, ENVIRONMENTAL

Journal of Polymers and the Environment Pub Date : 2025-01-11 DOI:10.1007/s10924-025-03496-6

Amir Kazemi, Mohammad Hossein Afshari, Hasan Baesmat, Saber Keshavarz, Fateme Zeinali, Shahla Zahiri, Elahe Torabi, Faranak Manteghi, Sohrab Rohani

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Abstract

The synthesis of nanoscale metal-organic frameworks (MOFs) is emerging as a promising method for targeted drug delivery in cancer therapy. In this study, unlike conventional solvothermal methods that require high temperatures, room-temperature synthesis of two Zn-MOF-74 variants was achieved using zinc nitrate and zinc acetate with triethylamine (TEA). The use of different anions allows precise control over the morphology and particle size of the MOF, optimizing drug loading in nanocarriers. Drug loading and release were evaluated using 5-fluorouracil (5-FU) as a model drug in both aqueous and ethanolic environments. The results showed that Zn-MOF-74 prepared with zinc acetate (R_A-MOF-74) at a 1:1 drug-to-nanocarrier ratio in ethanol exhibited superior drug adsorption and release characteristics. To enhance biocompatibility and controlled release, R_A-MOF-74 nanocarriers were coated with two biodegradable polymers, sodium alginate (ALG) and polydopamine (PDA), to improve stability at low pH and enhance release control. The release profiles of 5-FU from R_A-MOF-74 and its coated samples (PDA and ALG) were evaluated at different pH levels. In uncoated R_A-MOF-74, drug release at pH 7.4 and 8 was 48.4% and 59.1%, respectively, reaching 100% at pH 1.5. For the coated samples, 5-FU@R_A-MOF-74/ALG released 19.8% and 45.9% at pH 1.5 and 8, respectively, while 5-FU@R_A-MOF-74/PDA showed 25.2% and 40.8% release at pH 7.4 and 5.5. These results clearly highlight pH-sensitive release and the role of biocompatible coatings in enhancing controlled drug release, demonstrating the potential of Zn-MOF-74 with controlled morphology for pH-responsive delivery of 5-FU in cancer therapy, paving the way for future in vivo applications.

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室温合成ph响应MOF纳米载体用于肿瘤靶向药物递送

纳米级金属有机骨架（mof）的合成是一种很有前途的靶向药物递送方法。在本研究中，与传统的需要高温的溶剂热法不同，使用硝酸锌和乙酸锌与三乙胺（TEA）在室温下合成了两种Zn-MOF-74变体。使用不同的阴离子可以精确控制MOF的形态和粒径，优化纳米载体中的药物负载。以5-氟尿嘧啶（5-FU）为模型药物，在水环境和乙醇环境下对药物的负载和释放进行了评估。结果表明，以醋酸锌（RA-MOF-74）为载体，以1:1的药纳米比在乙醇中制备的Zn-MOF-74具有优异的药物吸附和释放特性。为了提高RA-MOF-74纳米载体的生物相容性和控释能力，我们将海藻酸钠（ALG）和聚多巴胺（PDA）两种可生物降解的聚合物包被在RA-MOF-74纳米载体上，以提高其在低pH下的稳定性和控释能力。研究了RA-MOF-74及其包被样品（PDA和ALG）在不同pH值下的5-FU释放谱。在未包被的RA-MOF-74中，pH为7.4和8时药物释放率分别为48.4%和59.1%，pH为1.5时药物释放率达到100%。对于包被样品，5-FU@RA-MOF-74/ALG在pH为1.5和8时的释放量分别为19.8%和45.9%，5-FU@RA-MOF-74/PDA在pH为7.4和5.5时的释放量分别为25.2%和40.8%。这些结果清楚地强调了ph敏感性释放和生物相容性涂层在增强药物控释中的作用，证明了具有可控形态的Zn-MOF-74在癌症治疗中ph响应性递送5-FU的潜力，为未来的体内应用铺平了道路。

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来源期刊

Journal of Polymers and the Environment 工程技术-高分子科学

CiteScore

9.50

自引率

7.50%

发文量

297

审稿时长

9 months

期刊介绍： The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.