A 3D-Printed Bone Scaffold of Carboxymethyl Chitosan/Gelatin/Akermanite: Synthesis and Evaluation

IF 4.7 3区工程技术 Q2 ENGINEERING, ENVIRONMENTAL

Journal of Polymers and the Environment Pub Date : 2024-12-30 DOI:10.1007/s10924-024-03484-2

Elsa Mamaghani, Mahmoud Azami, Mohammad Nikkhoo

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Abstract

In this study, carboxymethyl chitosan/gelatin/Akermanite (CMC/GEL/AK)-based scaffolds were prepared for bone tissue regeneration via 3D printing method. The bioactive AK was synthesized and used to fabricate the scaffolds. The AK powder was analysed through scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and X-ray diffraction (XRD). The porous scaffolds were fabricated and characterized to show their ability in bone tissue engineering (BTE). Degradation rate, swelling ratio, and mechanical properties of the scaffolds containing AK have been significantly increased. The scaffolds possess the interconnected networks with the pore size of about 300–900 μm. The mechanical strength increased up to 2.6 MPa by adding 20% AK to the scaffolds. In addition, cell viability and cell attachment studies exhibited the viability of up to 80%. This study confirms the potential of fabricated biocomposites in non-load-bearing bone defect regeneration.

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3d打印羧甲基壳聚糖/明胶/阿角石骨支架的合成与评价

本研究采用3D打印技术制备羧甲基壳聚糖/明胶/丙烯酸酯（CMC/GEL/AK）基支架，用于骨组织再生。合成了具有生物活性的AK并将其用于支架的制备。通过扫描电子显微镜（SEM）、傅里叶红外光谱（FTIR）、动态光散射（DLS）和x射线衍射（XRD）对AK粉末进行了分析。制备了多孔支架，并对其进行了表征，以显示其在骨组织工程中的应用能力。含有AK的支架的降解率、溶胀率和力学性能显著提高。该支架具有相互连接的网状结构，孔径约为300 ~ 900 μm。添加20% AK后，支架的机械强度可提高2.6 MPa。此外，细胞活力和细胞附着研究表明，细胞活力高达80%。本研究证实了合成生物复合材料在非承重骨缺损再生中的潜力。

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来源期刊

Journal of Polymers and the Environment 工程技术-高分子科学

CiteScore

9.50

自引率

7.50%

发文量

297

审稿时长

9 months

期刊介绍： The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.