A 3D-Printed Bone Scaffold of Carboxymethyl Chitosan/Gelatin/Akermanite: Synthesis and Evaluation

IF 4.7 3区工程技术 Q2 ENGINEERING, ENVIRONMENTAL

Journal of Polymers and the Environment Pub Date : 2024-12-30 DOI:10.1007/s10924-024-03484-2

Elsa Mamaghani, Mahmoud Azami, Mohammad Nikkhoo

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引用次数: 0

Abstract

In this study, carboxymethyl chitosan/gelatin/Akermanite (CMC/GEL/AK)-based scaffolds were prepared for bone tissue regeneration via 3D printing method. The bioactive AK was synthesized and used to fabricate the scaffolds. The AK powder was analysed through scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and X-ray diffraction (XRD). The porous scaffolds were fabricated and characterized to show their ability in bone tissue engineering (BTE). Degradation rate, swelling ratio, and mechanical properties of the scaffolds containing AK have been significantly increased. The scaffolds possess the interconnected networks with the pore size of about 300–900 μm. The mechanical strength increased up to 2.6 MPa by adding 20% AK to the scaffolds. In addition, cell viability and cell attachment studies exhibited the viability of up to 80%. This study confirms the potential of fabricated biocomposites in non-load-bearing bone defect regeneration.

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来源期刊

Journal of Polymers and the Environment 工程技术-高分子科学

CiteScore

9.50

自引率

7.50%

发文量

297

审稿时长

9 months

期刊介绍： The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.