TRANSLATIONAL APPLICATION OF COLD ATMOSPHERIC PLASMA IN PERIODONTOLOGY AND IMPLANTOLOGY: WHERE ARE WE? A SYSTEMATIC REVIEW OF IN VIVO STUDIES IN HUMAN AND ANIMAL MODELS

IF 4 4区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Evidence-Based Dental Practice Pub Date : 2025-01-23 DOI:10.1016/j.jebdp.2025.102096

GIORGIA STORNELLI , GIULIA PETRUCCI , VITO CARLO ALBERTO CAPONIO , ELOISA SARDELLA , GIUSEPPE BALICE , BEATRICE FEMMINELLA , MICHELE PAOLANTONIO , ILARIA CELA , TIRTHA RAJ ACHARYA , NAYANSI JHA , NAGENDRA KUMAR KAUSHIK , EUN HA CHOI , VALENTINA PUCA , ROSSELLA GRANDE , VITTORIA PERROTTI

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引用次数: 0

Abstract

Aim

The utilization of cold atmospheric plasma (CAP) in dentistry presents a promising avenue for novel therapeutic interventions. This systematic review of in vivo studies aimed at summarizing the existing evidence regarding the efficacy of CAP as a treatment for biofilms associated with periodontitis and peri-implantitis. The objective was to advance the definition and standardization of protocols and facilitate the integration of CAP treatment as a chair-side practice.

Materials and Methods

This review was registered in PROSPERO database (CRD42023404757), and a comprehensive search was conducted following PRISMA guidelines and using PubMed, Scopus, Web of Science, and Embase databases.

Results

In total, 9 in vivo studies were included, 1 on humans and 8 on animal models. A notable reduction in residual bacteria when CAP was combined with conventional therapies in both periodontitis and peri-implantitis models was observed. Biochemical and histological assays demonstrated a decrease in inflammatory cytokines within crevicular fluid and oral tissues.

Conclusions

Current evidence suggests that CAP shows promise for periodontitis and peri-implantitis treatment, but further clinical trials with larger cohorts and standardized protocols are needed to confirm its efficacy and safety.

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低温大气等离子体在牙周学和种植学中的转化应用：进展如何？系统回顾了人类和动物模型的体内研究

目的低温常压等离子体（CAP）在口腔医学中的应用为新的治疗手段提供了一条有前景的途径。本系统综述了体内研究，旨在总结现有证据，证明CAP治疗牙周炎和种植周炎相关生物膜的有效性。目的是促进协议的定义和标准化，并促进CAP治疗作为一种主席边实践的整合。材料和方法本综述在PROSPERO数据库注册（CRD42023404757），并根据PRISMA指南和PubMed、Scopus、Web of Science和Embase数据库进行全面检索。结果共纳入9项体内实验，1项人体实验，8项动物实验。观察到在牙周炎和种植周炎模型中，CAP与常规治疗联合使用时，残留细菌显著减少。生化和组织学分析显示，沟液和口腔组织中的炎症细胞因子减少。目前的证据表明，CAP对牙周炎和种植周炎的治疗有希望，但需要进一步的临床试验和更大的队列和标准化的方案来证实其有效性和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Evidence-Based Dental Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

6.00

自引率

16.70%

发文量

105

审稿时长

28 days

期刊介绍： The Journal of Evidence-Based Dental Practice presents timely original articles, as well as reviews of articles on the results and outcomes of clinical procedures and treatment. The Journal advocates the use or rejection of a procedure based on solid, clinical evidence found in literature. The Journal''s dynamic operating principles are explicitness in process and objectives, publication of the highest-quality reviews and original articles, and an emphasis on objectivity.