TRANSLATIONAL APPLICATION OF COLD ATMOSPHERIC PLASMA IN PERIODONTOLOGY AND IMPLANTOLOGY: WHERE ARE WE? A SYSTEMATIC REVIEW OF IN VIVO STUDIES IN HUMAN AND ANIMAL MODELS

IF 4.1 4区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Evidence-Based Dental Practice Pub Date : 2025-01-23 DOI:10.1016/j.jebdp.2025.102096

GIORGIA STORNELLI , GIULIA PETRUCCI , VITO CARLO ALBERTO CAPONIO , ELOISA SARDELLA , GIUSEPPE BALICE , BEATRICE FEMMINELLA , MICHELE PAOLANTONIO , ILARIA CELA , TIRTHA RAJ ACHARYA , NAYANSI JHA , NAGENDRA KUMAR KAUSHIK , EUN HA CHOI , VALENTINA PUCA , ROSSELLA GRANDE , VITTORIA PERROTTI

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Abstract

Aim

The utilization of cold atmospheric plasma (CAP) in dentistry presents a promising avenue for novel therapeutic interventions. This systematic review of in vivo studies aimed at summarizing the existing evidence regarding the efficacy of CAP as a treatment for biofilms associated with periodontitis and peri-implantitis. The objective was to advance the definition and standardization of protocols and facilitate the integration of CAP treatment as a chair-side practice.

Materials and Methods

This review was registered in PROSPERO database (CRD42023404757), and a comprehensive search was conducted following PRISMA guidelines and using PubMed, Scopus, Web of Science, and Embase databases.

Results

In total, 9 in vivo studies were included, 1 on humans and 8 on animal models. A notable reduction in residual bacteria when CAP was combined with conventional therapies in both periodontitis and peri-implantitis models was observed. Biochemical and histological assays demonstrated a decrease in inflammatory cytokines within crevicular fluid and oral tissues.

Conclusions

Current evidence suggests that CAP shows promise for periodontitis and peri-implantitis treatment, but further clinical trials with larger cohorts and standardized protocols are needed to confirm its efficacy and safety.

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来源期刊

Journal of Evidence-Based Dental Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

6.00

自引率

16.70%

发文量

105

审稿时长

28 days

期刊介绍： The Journal of Evidence-Based Dental Practice presents timely original articles, as well as reviews of articles on the results and outcomes of clinical procedures and treatment. The Journal advocates the use or rejection of a procedure based on solid, clinical evidence found in literature. The Journal''s dynamic operating principles are explicitness in process and objectives, publication of the highest-quality reviews and original articles, and an emphasis on objectivity.