Bioswitchable Polyurethane Implants: Enhancing Performance with 2D Nano Additives

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects Pub Date : 2025-02-01 DOI:10.1016/j.nanoso.2025.101454

Anushka Grace Binod , Payal Varma , Balasubramanian Kandasubramanian

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引用次数: 0

Abstract

Implants that can modify biological signals or environmental factors are now a focal point in the realm of biomedical applications. These groundbreaking devices hold immense potential to transform medical procedures and tools. Integrating 2D nano additives such as graphene, graphene oxide, and Mxene into Polyurethane (PU), due to their bioswitchability, durability, and shape memory capabilities make it an attractive material for bioswitchable implants. Although these materials have immense potential, they still face complications regarding their compatibility with living beings, capacity to bear mechanical stress, and regulated degradation rate. This can be improved by compiling them with biocompatible materials that enhance their properties. Various processing methods are explored for integrating nano additives into PU matrices, like electrospinning, 3D printing, solvent casting and particulate leaching, thermoplastic molding, and melt blending has been encompassed in this article. This review highlights PU-based bioswitchable implants’ advancements in dentistry, bone implants, drug delivery, tissue regeneration, and cancer therapy. Integrating nanomaterials enhances the implants' physical, biological, cytotoxic, and long-term monitoring profiles. The main focus is on employing robotic touch to interact with biological systems and operate implants dynamically. This research reveals that PU-based bioswitchable implants and robotic fingertips might revolutionize regenerative medicine by increasing patient outcomes.

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来源期刊

Nano-Structures & Nano-Objects Physics and Astronomy-Condensed Matter Physics

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

22 days

期刊介绍： Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .