Global prevalence of falls among older adults with cancer: A systematic review and meta-analysis

IF 3 3区医学 Q3 GERIATRICS & GERONTOLOGY

Journal of geriatric oncology Pub Date : 2025-02-15 DOI:10.1016/j.jgo.2025.102202

Ganesh Bushi , Shilpa Gaidhane , Ashok Kumar Balaraman , G. Padmapriya , Irwanjot Kaur , Madan Lal , Suhaib Iqbal , G.V. Siva Prasad , Atreyi Pramanik , Teena Vishwakarma , Praveen Malik , Promila Sharma , Ankit Punia , Megha Jagga , Mahendra Pratap Singh , Doddolla Lingamaiah , Muhammed Shabil , Rachana Mehta , Sanjit Sah , Quazi Syed Zahiruddin

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引用次数: 0

Abstract

Introduction

Falls are a significant health concern among older adults, particularly those with cancer, due to aging-related frailty, treatment-related adverse effects, and comorbidities. Existing reviews have highlighted the burden of falls in this population; however, the absence of a comprehensive meta-analysis to synthesize pooled results from relevant studies has limited the generalizability of their findings. This systematic review and meta-analysis aimed to estimate the global prevalence of falls among older adults with cancer and provide evidence to guide prevention efforts.

Materials and Methods

A systematic search of PubMed, Embase, and Web of Science databases was conducted through October 2024, following PRISMA 2020 guidelines. Studies reporting fall prevalence in patients with cancer aged 65 years or older were included. Pooled prevalence estimates were calculated using a random-effects meta-analysis.

Results

Seventy-six studies, including 177,212 participants, met the inclusion criteria. The pooled prevalence of falls was 24 % (95 % confidence interval [CI], 20; 28), with significant heterogeneity (I² = 100 %). Fall prevalence increased with follow-up duration: short-term 12 % (95 % CI, 5.2; 28.4), medium-term 23 % (95 % CI, 18.9; 29.5), and long-term 54 % (95 % CI, 14.9; 89.1) studies (p = 0.13). Older adults with breast cancer had the highest prevalence of falls at 31 % (95 % CI, 17; 48), while patients with colorectal cancer had the lowest at 15 % (95 % CI, 1; 78) (P ≤0.001). Fall prevalence ranged from 19 % in Australia to 24 % in North America (p = 0.89).

Discussion

Falls are frequent among older adults with cancer, with prevalence varying by cancer type, geographic region, and follow-up duration.

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全球老年癌症患者跌倒患病率：一项系统回顾和荟萃分析

由于衰老相关的虚弱、治疗相关的不良反应和合并症，跌倒是老年人特别是癌症患者的一个重要健康问题。现有的审查强调了这一人群的跌倒负担；然而，缺乏综合综合相关研究结果的综合荟萃分析限制了他们发现的普遍性。本系统综述和荟萃分析旨在估计全球老年癌症患者跌倒的患病率，并为指导预防工作提供证据。材料和方法按照PRISMA 2020指南，在2024年10月之前对PubMed、Embase和Web of Science数据库进行了系统搜索。研究报告了65岁及以上癌症患者的跌倒患病率。使用随机效应荟萃分析计算合并患病率估计值。结果76项研究，177,212名受试者符合纳入标准。跌倒的总发生率为24%(95%可信区间[CI], 20；28)，异质性显著（I2 = 100%）。随着随访时间的延长，跌倒患病率增加：短期12% (95% CI, 5.2；28.4)，中期23% (95% CI, 18.9；29.5)，长期54% (95% CI, 14.9；89.1)项研究（p = 0.13）。老年乳腺癌患者跌倒的发生率最高，为31% (95% CI, 17；48)，而结直肠癌患者最低，为15% (95% CI, 1；78) （p≤0.001）。秋季患病率从澳大利亚的19%到北美的24%不等（p = 0.89）。老年癌症患者经常跌倒，其患病率因癌症类型、地理区域和随访时间而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of geriatric oncology ONCOLOGY-GERIATRICS & GERONTOLOGY

CiteScore

5.30

自引率

10.00%

发文量

379

审稿时长

80 days

期刊介绍： The Journal of Geriatric Oncology is an international, multidisciplinary journal which is focused on advancing research in the treatment and survivorship issues of older adults with cancer, as well as literature relevant to education and policy development in geriatric oncology. The journal welcomes the submission of manuscripts in the following categories: • Original research articles • Review articles • Clinical trials • Education and training articles • Short communications • Perspectives • Meeting reports • Letters to the Editor.