Isolation of nontuberculous mycobacteria and Nocardia via mycobacterial culture from pulmonary specimens

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2025-02-15 DOI:10.1016/j.diagmicrobio.2025.116752

Hongli Sun , Wenjing Liu , Lingli Liu , Xuefeng Sun

{"title":"Isolation of nontuberculous mycobacteria and Nocardia via mycobacterial culture from pulmonary specimens","authors":"Hongli Sun , Wenjing Liu , Lingli Liu , Xuefeng Sun","doi":"10.1016/j.diagmicrobio.2025.116752","DOIUrl":null,"url":null,"abstract":"<div><div><em>Nontuberculous mycobacteria</em> (NTM) and <em>Nocardia</em> are often isolated via mycobacterial culture, yet their prevalence in various pulmonary specimens is uncertain. We retrieved mycobacterial culture results from pulmonary specimens from a tertiary hospital in China between January 2017 and July 2021. The prevalence of non-<em>Mycobacterium tuberculosis</em> (non-Mtb, including NTM and <em>Nocardia</em>) has surpassed Mtb, accounting for 1.7 times the rate of Mtb among all isolates. The frequency of non-Mtb positivity in sputum specimens was significantly higher compared to that in bronchoscopy specimens (3.7% vs 1.9%, <em>P</em> < 0.001). Furthermore, NTM accounted for 59.8% of all Mycobacterium isolates and 42.1% of patients with positive acid-fast staining. Multivariate logistic regression analysis identified several risk factors significantly associated with non-Mtb isolates compared to Mtb, including age over 45 years (adjusted odds ratio [aOR] 2.27), bronchiectasis (aOR 4.52), pulmonary interstitial disorder (aOR 2.11), chronic obstructive pulmonary disease (aOR 1.94), and non-diabetes (aOR 2.10).</div></div>","PeriodicalId":11329,"journal":{"name":"Diagnostic microbiology and infectious disease","volume":"111 4","pages":"Article 116752"},"PeriodicalIF":2.1000,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic microbiology and infectious disease","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0732889325000756","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Nontuberculous mycobacteria (NTM) and Nocardia are often isolated via mycobacterial culture, yet their prevalence in various pulmonary specimens is uncertain. We retrieved mycobacterial culture results from pulmonary specimens from a tertiary hospital in China between January 2017 and July 2021. The prevalence of non-Mycobacterium tuberculosis (non-Mtb, including NTM and Nocardia) has surpassed Mtb, accounting for 1.7 times the rate of Mtb among all isolates. The frequency of non-Mtb positivity in sputum specimens was significantly higher compared to that in bronchoscopy specimens (3.7% vs 1.9%, P < 0.001). Furthermore, NTM accounted for 59.8% of all Mycobacterium isolates and 42.1% of patients with positive acid-fast staining. Multivariate logistic regression analysis identified several risk factors significantly associated with non-Mtb isolates compared to Mtb, including age over 45 years (adjusted odds ratio [aOR] 2.27), bronchiectasis (aOR 4.52), pulmonary interstitial disorder (aOR 2.11), chronic obstructive pulmonary disease (aOR 1.94), and non-diabetes (aOR 2.10).

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.