Preparation of a metal‒organic framework glass‒based chiral stationary phase for HPLC enantiomer separation

Abstract

The development of a chiral stationary phase (CSP) based on new matrices is still necessary because of the rapid growth of new chiral drugs and the limitations of the silica gel matrix. For the first time, MOF glass agZIF-62 was used as a matrix to fabricate a chiral stationary phase (CSP) by coating cellulose-tris(3,5-dimethylphenylcarbamate) (CDMPC). These MOF glass-based CSPs can separate various racemic compounds, including metalaxyl, epoxiconazole, TSO, cis-metconazole, and triticonazole with resolution values (Rs) ranging from 1.22 to 4.58 and separation factors (α) ranging from 1.8 to 6.79. In addition, the HPLC enantiomer separation performances of MOF glass-based and MOF crystal-based CSPs were compared.