Exploring the phytochemical composition of Crepis heldreichiana (Kuntze) Greuter: A unique endemic species of Greece

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-02-15 DOI:10.1016/j.phytol.2025.01.1003

Christina Barda , Maria-Eleni Grafakou , Joerg Heilmann , Helen Skaltsa

引用次数: 0

Abstract

Within the genus Crepis of the Asteraceae family (Cichorieae), Crepis heldreichiana (Kuntze) Greuter is recognized as a native plant in the Greek flora, with a distribution limited to the Taigetos and Parnonas mountains of the Peloponnese.

Taking into consideration the restricted geographic range and the unexplored chemical profile of C. heldreichiana. This study was designed to unveil its phytochemical profile revealing 13 compounds, among which four are identified as sesquiterpene lactones, including a previously unreported one, as well as an apocaroteonoid, while the remaining are primarily phenolic derivatives.

Various spectrometric and spectroscopic techniques were employed to elucidate the structures of the isolated compounds. The relative configurations of the compounds were established through analysis of NMR spectroscopic and HRESIMS spectrometric data, complemented by CD spectroscopic measurements.

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探讨希腊特有种Crepis heldreichiana (Kuntze) Greuter的植物化学成分

在菊科（蝉科）的Crepis属中，Crepis heldreichiana (Kuntze) Greuter被认为是希腊植物区的原生植物，分布仅限于伯罗奔尼撒半岛的Taigetos和Parnonas山脉。考虑到heldreichiana有限的地理范围和未开发的化学剖面。本研究旨在揭示其植物化学特征，揭示13种化合物，其中4种被确定为倍半萜内酯，包括以前未报道的一种，以及类伪胡萝卜素，其余主要是酚类衍生物。各种光谱和光谱学技术被用来阐明分离化合物的结构。通过核磁共振光谱和hresms光谱数据分析，并辅以CD光谱测量，确定了化合物的相对构型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.