Exploration of antiurolithiatic properties of methanolic extract of rhizome of CyperusTegetumRoxb in ethylene glycol-induced urolithiatic rats

Abstract

Urolithiasis is known as urinary stone or kidney stone. It is the supersaturation of urine with the offending salt and crystallization. Crystals retained in the kidney can become a nucleus and form a stone-like structure. Novel therapeutic interventions are required for the treatment of urolithiasis with lower side effects. Cyperuspangorei Rottb.(synonyms- Cyperus Tegetum Roxb),is a CYPERACEAE family plant that is rich in bioactive phytochemicals and has shown promising pharmacological properties. The main goal of this study is to investigate the protective effects against urolithiasis of C.pangorei methanolic extract using ethylene glycol-induced kidney stones. Different groups of albino Wister rats received either a standard drug (50 mg/kg) of allopurinol or C.pangorei methanolic extract along with ethylene glycol (1 % v/v) except group I and group II, for a specific period. Group I received only a vehicle and Group II received a vehicle and ethylene glycol. After the specific time of duration, biochemical analysis (calcium, urea, uric acid, creatinine, phosphate, GPT, GOT) & MDA analysis indicate significant protective effects against urolithiasis in treated with C.pangorei methanolic extract as compared to the untreated group and this plant have an antioxidant effect. Biochemicals of calcium, urea, uric acid, creatinine, phosphate, GPT, and GOT were effectively reduced by plant extract in serum. Results of histopathology proved that this plant has an antiurolithiatic effect on ethylene glycol-induced urolithiasis in rats.