Sex differences in in vivo soft tissue compressive properties of the human hip in young adults: a comparison between passive vs active state

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2025-02-05 DOI:10.1016/j.jmbbm.2025.106904

Fatemeh Khorami , Numaira Obaid , Carolyn J. Sparrey

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Abstract

Hip injuries are a frequent outcome of falls. Studying the biomechanics of hip injuries requires a comprehensive understanding of soft tissue properties and their responses to external loads. Particularly, muscle activity is crucial in arresting a fall and is likely to affect soft tissue properties. Failing to consider muscle activation might result in incorrect conclusions regarding the processes underlying injuries and the efficacy of preventive strategies. Soft tissue response is also affected by loading rate, sex, and mechanical testing protocols, highlighting the need for precise experimental design and interpretation.

Forty individuals (age = 25.53 ± 3.41 years) were recruited (20 males and 20 females) to investigate the hip soft tissue response during a high-speed cyclic indentation testing. Muscle activity was recorded using electromyography (EMG) and soft tissue thickness was measured using ultrasound imaging. Peak force, energy, and tissue stiffness were measured using tissue indentation.

The hip soft tissue exhibited hysteresis and was nonlinear during loading. Sex differences in trochanteric soft tissue stiffness resulted in males having 38% higher peak force than females and absorbed energy was 32% higher in the active state than the passive state (in combined participants).

Characterizing the range of tissue responses for in vivo hip soft tissues emphasizes the natural variability in healthy human tissues and the need to consider the range of tissue behaviors in models, not just the average response. Both sex and muscle activation increased tissue mechanical variability and need to be considered in future physical and computational models of hip impact.

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.